Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.59 |
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29839704 | 1.00 | RAB9A (0.59) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL3534947 | 1.00 | RAB9A (0.59) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL28443608 | 0.83 | RAB9A (0.80) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL709664 | 0.81 | NPC1 (0.56) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL709663 | 0.81 | NPC1 (0.56) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL230838 | 0.79 | NPC1 (0.57) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL714134 | 0.79 | RAB9A (0.79) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL714135 | 0.79 | RAB9A (0.79) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL5099515 | 0.78 | RAB9A (0.66) | RAB9ANPC1KDM4ELMNAPKM | |
| SCHEMBL5099524 | 0.78 | RAB9A (0.66) | RAB9ANPC1KDM4ELMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103145613-B | Method for synthesizing (E)-3-[2-cyclopropyl-4-(4-fluorophenyl) quinolinyl-2-propenal | YELLOW RIVER DELTA JINGBO RES INST CHEMICAL IND CO LTD | 2015-04-08 | — | — | CN | claimed |
| CN-103145613-A | Method for synthesizing (E)-3-[2-cyclopropyl-4-(4-fluorophenyl) quinolinyl-2-propenal | YELLOW RIVER DELTA JINGBO CHEMICAL RES INST CO LTD | 2013-06-12 | — | — | CN | claimed |
| EP-4340835-A1 | METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE | METANOIA BIO INC. (US) | 2024-03-27 | — | — | EP | disclosed |
| EP-2261212-B1 | Preparation of quinoline-substituted carbamate derivatives | ABBVIE INC (US) | 2016-08-31 | — | — | EP | disclosed |
| EP-2409964-B1 | Process for the preparation of carbonate derivatives | ABBOTT LAB (US) | 2016-01-27 | — | — | EP | disclosed |
| CN-103145613-B | Method for synthesizing (E)-3-[2-cyclopropyl-4-(4-fluorophenyl) quinolinyl-2-propenal | YELLOW RIVER DELTA JINGBO RES INST CHEMICAL IND CO LTD | 2015-04-08 | — | — | CN | disclosed |
| CN-103145613-A | Method for synthesizing (E)-3-[2-cyclopropyl-4-(4-fluorophenyl) quinolinyl-2-propenal | YELLOW RIVER DELTA JINGBO CHEMICAL RES INST CO LTD | 2013-06-12 | — | — | CN | disclosed |
| EP-1192139-B1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBOTT LAB (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-2409964-A2 | Preparation of substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2012-01-25 | — | — | EP | disclosed |
| US-8071620-B2 | Carbamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2011-12-06 | — | — | US | disclosed |
| EP-2261212-A2 | Preparation of quinoline-substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2010-12-15 | — | — | EP | disclosed |
| EP-1192139-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | Abbott Laboratories (US) | 2002-04-03 | — | — | EP | disclosed |
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2002-01-31 | — | — | US | disclosed |
| JP-2001199962-A | METHOD FOR PRODUCING QUINOLYLACRYLONITRILE AND INTERMEDIATE THEREOF | UBE IND LTD | 2001-07-24 | — | — | JP | disclosed |
| WO-2001000582-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | ABBOTT LABORATORIES (US) | 2001-01-04 | — | — | WO | disclosed |
| US-6025390-A | Heteroaromatic pentadienoic acid derivatives useful as inhibitors of bone resorption | SMITHKLINE BEECHAM SPA (IT) | 2000-02-15 | — | — | US | disclosed |
| EP-0912539-A1 | HETEROAROMATIC PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | Smithkline Beecham S.p.A. (IT) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998001436-A1 | HETEROAROMATIC PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-01-15 | — | — | WO | disclosed |
| EP-0771796-A1 | Substituted S-triazines and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |
| US-4087549-A | Sulphonic acid containing indenyl derivatives | MERCK & CO., INC. (US) | 1978-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | RAB9A 1709/4885NPC1 980/4885KDM4E 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.