Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802375 | 0.80 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3R1PIK3CBMTOR | |
| SCHEMBL3728169 | 0.79 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPOLBHSD17B10 | |
| SCHEMBL29484630 | 0.78 | ALDH1A1 (0.56) | PIK3CAPTPN11POLBHSD17B10HTT | |
| SCHEMBL13555486 | 0.76 | CCNT1 (0.56) | CCNT1CCNA2CDK2CDK9PIK3CA | |
| SCHEMBL6700332 | 0.74 | PIK3CA (0.45) | CCNT1CCNA2CDK2CDK9PIK3CA | |
| SCHEMBL20920576 | 0.73 | KDM4E (0.63) | CCNT1CCNA2CDK2CDK9PIK3CA | |
| SCHEMBL3721198 | 0.73 | PTPN11 (0.56) | PIK3CAPIK3R1PTPN11POLBHSD17B10 | |
| SCHEMBL3112205 | 0.73 | HTT (0.58) | CCNT1CCNA2CDK2CDK9PIK3CA | |
| SCHEMBL4391823 | 0.73 | JAK2 (0.72) | JAK2 | |
| SCHEMBL5529145 | 0.72 | PIK3CA (0.60) | CCNT1CCNA2CDK2CDK9PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |