Sugi Predict

Sugi Predict / Compounds / SCHEMBL372145

SCHEMBL372145

SCHEMBL372145

c1ccc(P(c2ccccc2)c2cccc3c2-c2c(cccc2P(c2ccccc2)c2ccccc2)OCCCO3)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ITGB2 P05107 1/20 0.39
▸ ICAM1 P05362 1/20 0.39
▸ ITGAL P20701 1/20 0.39
▸ DRD1 P21728 2/20 0.38
▸ TDP1 Q9NUW8 2/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ SMN1; SMN2 Q16637 6/20 0.35
▸ LMNA P02545 2/20 0.35
▸ CRHBP P24387 2/20 0.35
▸ CRHR2 Q13324 2/20 0.35
▸ HTT P42858 1/20 0.35
▸ NPC1 O15118 5/20 0.34
▸ RAB9A P51151 5/20 0.34
▸ GAA P10253 1/20 0.34
▸ KDM1A O60341 1/20 0.33
▸ MAOA P21397 1/20 0.33
▸ MAOB P27338 1/20 0.33
▸ KMT2A Q03164 1/20 0.31
▸ ESR1 P03372 1/20 0.31
▸ ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3136613 0.97 ITGB2 (0.39) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL20351197 0.95 ITGB2 (0.38) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL3133241 0.95 ITGB2 (0.38) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL13243539 0.95 ITGB2 (0.38) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL3132985 0.93 ITGB2 (0.46) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL19928557 0.91 DRD1 (0.36) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL18979231 0.91 DRD1 (0.35) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL9913796 0.88 DRD1 (0.36) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL3136653 0.86 ABCG2 (0.46) ITGB2ICAM1ITGALDRD1TDP1
SCHEMBL21201776 0.85 DRD1 (0.32) ITGB2ICAM1ITGALDRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 214 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111212843-B Boric acid derivatives and synthesis thereof QPEX生物制药有限公司 2025-05-16 — — CN claimed
EP-3694864-B1 BORONIC ACID DERIVATIVES AND SYNTHESIS THEREOF QPEX BIOPHARMA INC (US) 2025-03-05 — — EP claimed
CN-114349648-B Preparation method of chiral amine compound 深圳先进技术研究院 2024-08-09 — — CN claimed
WO-2024108774-A1 METAL-CATALYZED DOUBLE HYDROBORATION OF NITROGEN HETEROCYCLICS GUANGDONG TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY (CN) 2024-05-30 — — WO claimed
US-20240002400-A1 ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES AMGEN INC. (US) 2024-01-04 — — US claimed
EP-4251604-A1 ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES Amgen Inc. (US) 2023-10-04 — — EP claimed
CN-116745258-A Enantioselective alkenylation of aldehydes 安进公司 2023-09-12 — — CN claimed
WO-2023109213-A1 METHOD FOR PREPARING CHIRAL AMINE COMPOUND 深圳先进技术研究院 2023-06-22 — — WO claimed
WO-2022127320-A1 INTERMEDIATE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 四川大学 2022-06-23 — — WO claimed
WO-2022115400-A1 ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES AMGEN INC. (US) 2022-06-02 — — WO claimed
EP-3344605-B1 METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF MERCK PATENT GMBH (DE) 2020-05-13 — — EP claimed
US-10273213-B2 Method for the production of praziquantel and precursors thereof MERCK PATENT GMBH (DE) 2019-04-30 — — US claimed
US-20180251428-A1 METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF MERCK PATENT GMBH (DE) 2018-09-06 — — US claimed
EP-3344605-A1 METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF Merck Patent GmbH (DE) 2018-07-11 — — EP claimed
EP-2531486-B1 NOVEL PROCESS FOR THE PREPARATION OF NITROGEN SUBSTITUTED AMINOTETRALINS DERIVATIVES UCB BIOPHARMA SPRL (BE) 2017-06-21 — — EP claimed
WO-2017036577-A1 METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF MERCK PATENT GMBH (DE) 2017-03-09 — — WO claimed
US-8563752-B2 Process for the production of carnitine by cycloaddition LONZA LTD. (CH) 2013-10-22 — — US claimed
EP-2531486-A2 NOVEL PROCESS FOR THE PREPARATION OF NITROGEN SUBSTITUTED AMINOTETRALINS DERIVATIVES UCB Pharma GmbH (DE) 2012-12-12 — — EP claimed
US-20120302790-A1 Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives UCB PHARMA, S.A. (BE) 2012-11-29 — — US claimed
WO-2011095539-A2 NOVEL PROCESS FOR THE PREPARATION OF NITROGEN SUBSTITUTED AMINOTETRALINS DERIVATIVES UCB PHARMA GMBH (DE) 2011-08-11 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120302790-A1 Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives AADAT, AANAT, ASNS ITGB2 4360/4885ICAM1 4848/4885ITGAL 3786/4885
US-10273213-B2 Method for the production of praziquantel and precursors thereof CYP51A1, POR, DHPS ITGB2 3702/4885ICAM1 4817/4885ITGAL 2306/4885
US-20240002400-A1 ENANTIOSELECTIVE ALKENYLATION OF ALDEHYDES MCL1, BAK1, BCL2A1 ITGB2 4294/4885ICAM1 1052/4885ITGAL 4407/4885
US-20180251428-A1 METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF CYP51A1, POR, DHPS ITGB2 3702/4885ICAM1 4817/4885ITGAL 2306/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.