Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 18/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730591 | 0.84 | ROCK2 (0.42) | ROCK2ROCK1AAK1 | |
| SCHEMBL2039605 | 0.80 | FYN (0.40) | — | |
| SCHEMBL29253578 | 0.78 | AKT1 (0.41) | ROCK2ROCK1 | |
| SCHEMBL6541679 | 0.76 | CA1 (0.38) | — | |
| SCHEMBL733083 | 0.76 | PLAU (0.43) | ROCK2ROCK1 | |
| SCHEMBL2581867 | 0.76 | METAP2 (0.53) | ROCK2ROCK1 | |
| SCHEMBL19398634 | 0.74 | ROCK2 (0.59) | ROCK2ROCK1 | |
| SCHEMBL693820 | 0.74 | CA12 (0.39) | — | |
| SCHEMBL2041601 | 0.73 | CYP2A6 (0.48) | — | |
| SCHEMBL9268604 | 0.73 | ABL1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108581-B | Tieback benzamide derivatives as potent ROCK inhibitors | 百时美施贵宝公司 | 2020-06-23 | — | — | CN | disclosed |
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |