Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238995 | 0.84 | KMT2A (0.54) | KMT2AHTTTDP1MEN1KDM4E | |
| SCHEMBL7510181 | 0.81 | HTT (0.63) | KMT2AHTTPOLBMAPK1TDP1 | |
| SCHEMBL19741751 | 0.80 | — | — | |
| SCHEMBL965286 | 0.80 | KMT2A (0.82) | KMT2AHTTPOLBMAPK1RAB9A | |
| SCHEMBL7509981 | 0.80 | HTT (0.57) | KMT2AHTTPOLBMAPK1TDP1 | |
| SCHEMBL4803949 | 0.78 | KMT2A (0.78) | KMT2AHTTMAPK1RAB9ATDP1 | |
| SCHEMBL966438 | 0.78 | KMT2A (0.78) | KMT2AHTTMAPK1RAB9ATDP1 | |
| SCHEMBL17273858 | 0.78 | KMT2A (0.78) | KMT2AHTTMAPK1RAB9ATDP1 | |
| SCHEMBL7514353 | 0.78 | HTT (0.55) | KMT2AHTTPOLBMAPK1TDP1 | |
| SCHEMBL13674468 | 0.77 | KMT2A (0.83) | KMT2AHTTBRD4POLBFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203577-A1 | Azepinoindole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2009-08-13 | — | — | US | claimed |
| US-20140221277-A1 | Method For Elevating Prolactin In Mammals | CARA THERAPEUTICS, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20130012431-A1 | Method For Elevating Prolactin In Mammals | CARA THERAPEUTICS, INC. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8217000-B2 | Method for elevating prolactin in mammals | CARA THERAPEUTICS, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-20100029575-A1 | N-Oxides of Kappa Receptor Peptides | CARA THERAPEUTICS, INC. | 2010-02-04 | — | — | US | disclosed |
| US-20090312271-A1 | Method For Elevating Prolactin in Mammals | CARA THERAPEUTICS INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090203577-A1 | Azepinoindole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| EP-2040733-A2 | METHOD FOR ELEVATING PROLACTIN IN MAMMALS | Cara Therapeutics, Inc. (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-2029617-A2 | N-OXIDES OF KAPPA OPIOID RECEPTOR PEPTIDES | Cara Therapeutics, Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1373234-B1 | UROKINASE INHIBITORS | WILEX AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| US-5811576-A | 1-CARBOXY-2-LOWERALKYL-3,4,6-TRI(HALO)BENZENES; GRAMPOSITIVE AND-NEGATIVE BACTERIA; INFECTIONS; STERILIZATION OF MEDICAL EQUIPMENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-09-22 | — | — | US | disclosed |
| US-5723648-A | Intermediates for anti-microbial benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0823413-A2 | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |
| US-5591744-A | 1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLATE DERIVATIVES; MICROBIOCIDES | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1997-01-07 | — | — | US | disclosed |
| US-5563138-A | 4-OXOQUINOLINE-3-CARBOXYLIC ACID COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1996-10-08 | — | — | US | disclosed |
| EP-0287951-B1 | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents | OTSUKA PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5495020-A | CHEMICAL INTERMEDIATE FOR BACTERICIDES, MICROBIOCIDES, DISINFECTANTS; SIDE EFFECT REDUCTION, ABSORPTION | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1996-02-27 | — | — | US | disclosed |
| US-5290934-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-03-01 | — | — | US | disclosed |
| EP-0565132-A2 | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-13 | — | — | EP | disclosed |
| EP-0287951-A2 | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029575-A1 | N-Oxides of Kappa Receptor Peptides | OPRD1, OPRK1, OPRM1 | KMT2A 2362/4885HTT 3293/4885BRD4 3834/4885 |
| US-20130012431-A1 | Method For Elevating Prolactin In Mammals | PRLHR, OPRK1, OPRL1 | KMT2A 1918/4885HTT 1182/4885BRD4 3483/4885 |
| US-20090312271-A1 | Method For Elevating Prolactin in Mammals | PRLHR, OPRK1, OPRL1 | KMT2A 1918/4885HTT 1182/4885BRD4 3483/4885 |
| US-20140221277-A1 | Method For Elevating Prolactin In Mammals | PRLHR, OPRK1, OPRL1 | KMT2A 1918/4885HTT 1182/4885BRD4 3483/4885 |
| US-20090203577-A1 | Azepinoindole Derivatives As Pharmaceutical Agents | NR1H4, NR1I2, GPBAR1 | KMT2A 4612/4885HTT 4543/4885BRD4 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.