Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 11/20 | 0.53 |
| ▸ | GRM5 | P41594 | 10/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
| ▸ | GABRE | P78334 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19284578 | 0.85 | PDK4 (0.65) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL4879856 | 0.81 | HTR6 (0.56) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL31150581 | 0.81 | PDK4 (0.67) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL21855632 | 0.81 | PDK4 (0.67) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL3436385 | 0.81 | PDK4 (0.69) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL19284673 | 0.80 | PDK4 (0.62) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL3715657 | 0.79 | PDK4 (0.56) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL6847847 | 0.78 | PDK4 (0.69) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL14540703 | 0.78 | HTR6 (0.70) | PDK4HTR6GRM1GRM5NAMPT | |
| SCHEMBL5749286 | 0.77 | HTR6 (0.52) | PDK4HTR6GRM1GRM5SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2211618-A1 | PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | Glaxo Group Limited (GB) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009049113-A1 | PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-04-16 | — | — | WO | disclosed |