Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.50 |
| ▸ | BCR | P11274 | 6/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186173 | 0.91 | ABL1 (0.48) | ABL1BCRSLC6A7KCNH2 | |
| SCHEMBL3722384 | 0.91 | ABL1 (0.48) | ABL1BCRSLC6A7KCNH2ALDH1A1 | |
| SCHEMBL3721461 | 0.90 | RIPK1 (0.48) | ABL1BCRSLC6A7KCNH2ALDH1A1 | |
| SCHEMBL4177025 | 0.89 | ABL1 (0.46) | ABL1BCRSLC6A7TGFBR1 | |
| SCHEMBL3663458 | 0.88 | TGFBR1 (0.52) | ABL1BCRSLC6A7TGFBR1HPGD | |
| SCHEMBL3718285 | 0.88 | CCNC (0.53) | L3MBTL1RIPK1CCNCCDK8KDM4E | |
| SCHEMBL4177554 | 0.86 | ABL1 (0.51) | ABL1BCRSLC6A7KCNH2HPGD | |
| SCHEMBL3727963 | 0.84 | ABL1 (0.50) | ABL1BCRSLC6A7KCNH2L3MBTL1 | |
| SCHEMBL3723755 | 0.82 | L3MBTL1 (0.53) | ABL1BCRSLC6A7KCNH2ALDH1A1 | |
| SCHEMBL3726132 | 0.82 | ABL1 (0.48) | ABL1BCRSLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242742-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2015-12-02 | — | — | EP | disclosed |
| EP-2242742-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009087212-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |