Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 7/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.49 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18664384 | 0.85 | HRH3 (0.64) | AOC3TAAR1HRH3 | |
| SCHEMBL2568377 | 0.84 | TAAR1 (0.55) | AOC3TAAR1HRH3 | |
| Hydrochloric Acid SCHEMBL20497358 | 0.83 | HRH3 (0.61) | AOC3TAAR1HRH3 | |
| SCHEMBL3794460 | 0.82 | TAAR1 (0.70) | TAAR1HRH3NOS3NOS1NOS2 | |
| SCHEMBL7326388 | 0.82 | AOC3 (0.58) | AOC3PNPLA2HDAC6 | |
| SCHEMBL28247640 | 0.81 | TAAR1 (0.74) | AOC3TAAR1HRH3PLGPLAU | |
| SCHEMBL19698856 | 0.80 | PNPLA2 (0.56) | AOC3PNPLA2HDAC6 | |
| SCHEMBL3791745 | 0.80 | LOXL2 (0.60) | TAAR1HRH3NOS3NOS1NOS2 | |
| SCHEMBL3727224 | 0.79 | TAAR1 (0.54) | TAAR1HRH3NOS3NOS1NOS2 | |
| SCHEMBL348900 | 0.79 | ALDH1A1 (0.48) | HDAC6NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |