Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.58 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18297788 | 0.82 | PRKCI (0.76) | PRKCIFYNACMSDCHRNB4CHRNA3 | |
| SCHEMBL3723883 | 0.82 | AOC3 (0.62) | AOC3PNPLA2HDAC6 | |
| SCHEMBL16578698 | 0.81 | PRKCI (0.68) | PRKCIFYNACMSDMGLLCHRNB4 | |
| SCHEMBL19698856 | 0.80 | PNPLA2 (0.56) | AOC3APPPNPLA2HDAC6 | |
| SCHEMBL4191589 | 0.80 | PRKCI (0.72) | PRKCIFYNACMSDCHRNB4CHRNA3 | |
| SCHEMBL1520795 | 0.79 | PRKCI (0.61) | PRKCIACMSDMGLLCHRNB4CHRNA3 | |
| SCHEMBL27332 | 0.79 | ALDH1A1 (0.54) | PRKCIFYNAPPHDAC6 | |
| SCHEMBL249824 | 0.78 | PRKCI (0.70) | AOC3PRKCIFYNACMSDCHRNB4 | |
| SCHEMBL30108284 | 0.78 | PRKCI (0.70) | AOC3PRKCIFYNACMSDCHRNB4 | |
| SCHEMBL13766439 | 0.78 | PRKCI (0.59) | PRKCIFYNACMSDMGLLCHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| EP-0693062-A1 | HETEROCYCLIC DERIVATIVES IN THE TREATMENT OF ISCHAEMIA AND RELATED DISEASES | SYNTEX PHARMACEUTICALS LTD. (GB) | 1996-01-24 | — | — | EP | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |
| WO-1994024116-A1 | HETEROCYCLIC DERIVATIVES IN THE TREATMENT OF ISCHAEMIA AND RELATED DISEASES | SYNTEX PHARMACEUTICALS LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |