SCHEMBL3724329

SCHEMBL3724329

COc1ccc2c(n1)N(c1ccc3c(c1)CCCC3C(NC(=O)O)C(C)(C)C)C(=O)CN2

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 1/20 0.31
CRBN Q96SW2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3026890 0.81 KDM4C (0.40) KDM4C
SCHEMBL3725917 0.76 FLT3 (0.35)
SCHEMBL3024862 0.74 CA1 (0.39) CRBN
SCHEMBL3020288 0.69 RIPK1 (0.36) CRBN
SCHEMBL3025534 0.69 KDM4C (0.33) KDM4C
SCHEMBL3724009 0.69 GAA (0.33)
SCHEMBL3662145 0.68 BRD4 (0.38)
SCHEMBL3724011 0.68 GAA (0.33)
SCHEMBL3012194 0.65 RIPK1 (0.33)
SCHEMBL3023008 0.64 HTR2C (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2139898-A1 COMPOUNDS Glaxo Group Limited (GB) 2010-01-06 EP disclosed
WO-2008128961-A1 COMPOUNDS GLAXO GROUP LIMITED (GB) 2008-10-30 WO disclosed