Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 6/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.46 |
| ▸ | MINK1 | Q8N4C8 | 5/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.46 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.46 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242198 | 0.86 | MAPK9 (0.42) | MAP4K4MAPK9CSNK1DCSNK1A1MINK1 | |
| SCHEMBL3525962 | 0.83 | PRKD3 (0.48) | MAP4K4MAPK9CSNK1DCSNK1A1MINK1 | |
| SCHEMBL3523202 | 0.81 | KMO (0.40) | F2RL3ADORA2AADORA1KMOTGFBR1 | |
| SCHEMBL13368329 | 0.77 | KMO (0.51) | MAPK9CSNK1DCSNK1A1F2RL3ADORA2A | |
| SCHEMBL3528770 | 0.75 | ALPL (0.47) | F2RL3KMOPDE3BPDE3AFEN1 | |
| SCHEMBL3527167 | 0.69 | PDE3B (0.49) | F2RL3ADORA2AADORA1KMOTGFBR1 | |
| SCHEMBL4923880 | 0.69 | MAPK9 (0.67) | MAP4K4MAPK9CSNK1DCSNK1A1MINK1 | |
| SCHEMBL3529079 | 0.69 | NPC1 (0.51) | ADORA2AADORA1TGFBR1TP53KDM4E | |
| SCHEMBL14525382 | 0.69 | NPC1 (0.51) | TP53KDM4ENPC1ALDH1A1NFKB1 | |
| SCHEMBL24080854 | 0.67 | HCRTR2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139329-A1 | NOVEL IMIDAZO BASED HETEROCYCLES | Abbott Laboratories (US) | 2010-01-06 | — | — | EP | disclosed |
| US-20080249305-A1 | Novel imidazole based heterocycles | ABBOTT LABORATORIES | 2008-10-09 | — | — | US | disclosed |
| US-20080249305-A1 | Novel imidazole based heterocycles | ABBOTT LABORATORIES | 2008-10-09 | — | — | US | disclosed |
| US-20080249305-A1 | Novel imidazole based heterocycles | ABBOTT LABORATORIES | 2008-10-09 | — | — | US | disclosed |
| US-20080242862-A1 | Novel imidazo based heterocycles | ABBOTT LABORATORIES | 2008-10-02 | — | — | US | disclosed |
| US-20080242862-A1 | Novel imidazo based heterocycles | ABBOTT LABORATORIES | 2008-10-02 | — | — | US | disclosed |
| US-20080242862-A1 | Novel imidazo based heterocycles | ABBOTT LABORATORIES | 2008-10-02 | — | — | US | disclosed |
| WO-2008118485-A1 | NOVEL IMIDAZO BASED HETEROCYCLES | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008118485-A1 | NOVEL IMIDAZO BASED HETEROCYCLES | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242862-A1 | Novel imidazo based heterocycles | CDK4, CDK2, MAP3K15 | MAP4K4 22/4885MAPK9 274/4885CSNK1D 669/4885 |
| US-20080249305-A1 | Novel imidazole based heterocycles | MAP3K5, MAP3K15, MAP3K20 | MAP4K4 25/4885MAPK9 249/4885CSNK1D 743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.