Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 8/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721342 | 0.90 | GPR119 (0.39) | TRPA1CTSAEPHX2 | |
| SCHEMBL893706 | 0.85 | HDAC1 (0.42) | TRPA1TACR1GHSRSYK | |
| SCHEMBL3727369 | 0.84 | TACR1 (0.44) | TRPA1TACR1GHSRNR1H2NR1H3 | |
| SCHEMBL894253 | 0.83 | ALDH1A1 (0.53) | TRPA1 | |
| SCHEMBL10203302 | 0.83 | ALDH1A1 (0.45) | — | |
| SCHEMBL893785 | 0.83 | ALDH1A1 (0.45) | — | |
| SCHEMBL893889 | 0.81 | TRPA1 (0.40) | TRPA1TACR1GHSR | |
| SCHEMBL893760 | 0.76 | TRPA1 (0.58) | TRPA1 | |
| SCHEMBL893297 | 0.76 | TRPA1 (0.50) | TRPA1EPHX2 | |
| SCHEMBL893761 | 0.74 | TRPA1 (0.48) | TRPA1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |