Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL450879 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL7468390 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL3961853 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL9423475 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL7472174 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL439062 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL9423564 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL439063 | 0.83 | PRMT5 (0.54) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL9844160 | 0.82 | PRMT5 (0.60) | PRMT5WDR77PKMALDH1A1LMNA | |
| SCHEMBL58865 | 0.82 | PRMT5 (0.60) | PRMT5WDR77PKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007408-A2 | INTERMEDIATES 2-(2-CHLORO-5-HYDROXY-4-METHYLCARBAMOYLPHENOXY)-2-METHYLPROPIONIC ACID TERT-BUTYL ESTER AND GLYCIDYL BENZENE SULFONATES OR SALTS THEREOF AND THE PROCESS FOR PREPARATION OF SAID INTERMEDIATES | ASTRAZENECA AB (SE) | 2010-01-21 | — | — | WO | disclosed |