Sugi Predict

Sugi Predict / Compounds / SCHEMBL58865

SCHEMBL58865

SCHEMBL58865

O=S(=O)(OCC1CO1)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 1/20 0.60
▸ WDR77 Q9BQA1 1/20 0.60
▸ TDP1 Q9NUW8 1/20 0.52
▸ LMNA P02545 3/20 0.49
▸ ALDH1A1 P00352 3/20 0.49
▸ PKM P14618 2/20 0.49
▸ GAA P10253 1/20 0.49
▸ GLA P06280 1/20 0.43
▸ MGLL Q99685 2/20 0.42
▸ TP53 P04637 1/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ HIF1A Q16665 1/20 0.42
▸ MAPK1 P28482 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ PARL Q9H300 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9844160 1.00 PRMT5 (0.60) PRMT5WDR77TDP1LMNAALDH1A1
SCHEMBL17193271 0.89 PRMT5 (0.51) PRMT5WDR77TDP1LMNAALDH1A1
SCHEMBL17193256 0.85 PRMT5 (0.48) PRMT5WDR77TDP1LMNAALDH1A1
SCHEMBL3961853 0.82 PRMT5 (0.54) PRMT5WDR77TDP1LMNAALDH1A1
SCHEMBL7468390 0.82 PRMT5 (0.54) PRMT5WDR77TDP1LMNAALDH1A1
SCHEMBL7472174 0.82 PRMT5 (0.54) PRMT5WDR77TDP1LMNAALDH1A1
SCHEMBL439062 0.82 PRMT5 (0.54) PRMT5WDR77LMNAALDH1A1PKM
SCHEMBL439063 0.82 PRMT5 (0.54) PRMT5WDR77LMNAALDH1A1PKM
SCHEMBL9423564 0.82 PRMT5 (0.54) PRMT5WDR77TDP1LMNAALDH1A1
SCHEMBL3725233 0.82 PRMT5 (0.54) PRMT5WDR77TDP1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101501016-B Preparation method of chiral 2-hydroxymethyl-1, 4-benzodioxane compound AHN GOOK PHARMACEUTICAL CO LTD 2012-10-24 — — CN claimed
US-20120130082-A1 1-Substituted-4-Nitroimidazole Compound and Method for Preparing the Same OTSUKA PHARMACEUTICAL CO., LTD. 2012-05-24 — — US claimed
WO-2010007408-A2 INTERMEDIATES 2-(2-CHLORO-5-HYDROXY-4-METHYLCARBAMOYLPHENOXY)-2-METHYLPROPIONIC ACID TERT-BUTYL ESTER AND GLYCIDYL BENZENE SULFONATES OR SALTS THEREOF AND THE PROCESS FOR PREPARATION OF SAID INTERMEDIATES ASTRAZENECA AB (SE) 2010-01-21 — — WO claimed
CN-101501016-A Preparation method of chiral 2-hydroxymethyl-1, 4-benzodioxane compound AHN GOOK PHARMA CO LTD (KR) 2009-08-05 — — CN claimed
WO-2009011654-A1 PROCESS FOR THE PREPARATION OF CYCLIC SPIROPIPERIDINES ASTRAZENECA AB (SE) 2009-01-22 — — WO claimed
WO-2009011653-A1 A PROCESS FOR THE PREPARATION OF INTERMEDIATES AND THEIR US IN THE SYNTHESIS OF SPIROPIPERIDINE COMPOUNDS ASTRAZENECA AB (SE) 2009-01-22 — — WO claimed
US-20080097107-A1 1-substituted-4-nitroimidazole compound and method for preparing the same OTSUKA PHARMACEUTICAL CO. LTD. 2008-04-24 — — US claimed
CN-1326840-C 1-substituted-4-nitroimidazole compounds and process for preparing same OTSUKA PHARMA CO LTD (JP) 2007-07-18 — — CN claimed
US-20060079697-A1 1-substituted-4-nitroimidazole compound and process for producing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-04-13 — — US claimed
CN-1692103-A 1-substituted-4-nitroimidazole compounds and process for preparing same OTSUKA PHARMA CO LTD (JP) 2005-11-02 — — CN claimed
EP-1553088-A1 1-SUBSTITUTED 4-NITROIMIDAZOLE COMPOUND AND PROCESS FOR PRODUCING THE SAME Otsuka Pharmaceutical Company, Limited (JP) 2005-07-13 — — EP claimed
US-5463061-A Process for production of glycide derivative MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-10-31 — — US claimed
EP-0335158-B1 Nitrogen containing polymeric compounds BAYER AG (DE) 1994-07-06 — — EP claimed
US-5093470-A Paper of high wet strength BAYER AKTIENGESELLSCHAFT (DE) 1992-03-03 — — US claimed
US-5082527-A Polyamine-epoxy resins, wet strength additive for paper BAYER AKTIENGESELLSCHAFT (DE) 1992-01-21 — — US claimed
CN-114929691-A Bicyclic compounds and uses thereof 爱思开生物制药株式会社 2022-08-19 — — CN disclosed
US-10767275-B2 Aqueous copper plating baths and a method for deposition of copper or copper alloy onto a substrate ATOTECH DEUTSCHLAND GMBH (DE) 2020-09-08 — — US disclosed
US-5093470-A Paper of high wet strength BAYER AKTIENGESELLSCHAFT (DE) 1992-03-03 — — US disclosed
US-5082527-A Polyamine-epoxy resins, wet strength additive for paper BAYER AKTIENGESELLSCHAFT (DE) 1992-01-21 — — US disclosed
EP-0454385-A1 Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives ORTHO PHARMACEUTICAL CORPORATION (US) 1991-10-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120130082-A1 1-Substituted-4-Nitroimidazole Compound and Method for Preparing the Same CBR1, CBR3, DCXR PRMT5 342/4885WDR77 2294/4885TDP1 3348/4885
US-20060079697-A1 1-substituted-4-nitroimidazole compound and process for producing the same CBR1, CBR3, DCXR PRMT5 337/4885WDR77 2620/4885TDP1 3453/4885
US-20080097107-A1 1-substituted-4-nitroimidazole compound and method for preparing the same CBR1, CBR3, DCXR PRMT5 342/4885WDR77 2294/4885TDP1 3348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.