Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | PARL | Q9H300 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58865 | 1.00 | PRMT5 (0.60) | PRMT5WDR77TDP1LMNAALDH1A1 | |
| SCHEMBL17193271 | 0.89 | PRMT5 (0.51) | PRMT5WDR77TDP1LMNAALDH1A1 | |
| SCHEMBL17193256 | 0.85 | PRMT5 (0.48) | PRMT5WDR77TDP1LMNAALDH1A1 | |
| SCHEMBL3961853 | 0.82 | PRMT5 (0.54) | PRMT5WDR77TDP1LMNAALDH1A1 | |
| SCHEMBL7468390 | 0.82 | PRMT5 (0.54) | PRMT5WDR77TDP1LMNAALDH1A1 | |
| SCHEMBL7472174 | 0.82 | PRMT5 (0.54) | PRMT5WDR77TDP1LMNAALDH1A1 | |
| SCHEMBL439062 | 0.82 | PRMT5 (0.54) | PRMT5WDR77LMNAALDH1A1PKM | |
| SCHEMBL439063 | 0.82 | PRMT5 (0.54) | PRMT5WDR77LMNAALDH1A1PKM | |
| SCHEMBL9423564 | 0.82 | PRMT5 (0.54) | PRMT5WDR77TDP1LMNAALDH1A1 | |
| SCHEMBL3725233 | 0.82 | PRMT5 (0.54) | PRMT5WDR77TDP1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1033326-C | Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives | ORTHO PHARMA CORP (US) | 1996-11-20 | — | — | CN | disclosed |
| CN-1055930-A | The preparation method of the optically active isomer of the purinyl piperazine derivative that 6-replaces | ORTHO PHARMA CORP (US) | 1991-11-06 | — | — | CN | disclosed |
| EP-0454385-A1 | Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-10-30 | — | — | EP | disclosed |