Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.47 |
| ▸ | IDH2 | P48735 | 2/20 | 0.47 |
| ▸ | FPR2 | P25090 | 4/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724700 | 0.85 | SCN9A (0.51) | SCN9AFPR2ADORA3CASP1 | |
| SCHEMBL3727419 | 0.85 | SCN9A (0.52) | SCN9AFPR2ADORA3VCPCASP1 | |
| SCHEMBL3717581 | 0.84 | PTGS1 (0.56) | SCN9AFPR2ADORA3VCPCASP1 | |
| SCHEMBL3725441 | 0.82 | IDH2 (0.48) | IDH2ADORA3VCPIDH1 | |
| SCHEMBL3721124 | 0.80 | MAPT (0.64) | — | |
| SCHEMBL3718623 | 0.78 | KDM4E (0.58) | SCN9AVCP | |
| SCHEMBL3717789 | 0.78 | SCN9A (0.53) | SCN9A | |
| SCHEMBL3722100 | 0.78 | SCN9A (0.52) | SCN9AFPR2 | |
| SCHEMBL3727125 | 0.78 | PTGS2 (0.48) | SCN9AFPR2ADORA3VCPCASP1 | |
| SCHEMBL3720230 | 0.78 | VCP (0.51) | SCN9AFPR2VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |