Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.52 |
| ▸ | FPR2 | P25090 | 3/20 | 0.50 |
| ▸ | TRPV3 | Q8NET8 | 5/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722102 | 0.83 | TRPV3 (0.53) | TRPV3CYP11B2 | |
| SCHEMBL3724700 | 0.81 | SCN9A (0.51) | SCN9AFPR2 | |
| SCHEMBL3727419 | 0.81 | SCN9A (0.52) | SCN9AFPR2 | |
| SCHEMBL3721092 | 0.81 | SCN9A (0.50) | SCN9AFPR2 | |
| SCHEMBL3721016 | 0.80 | SCN9A (0.48) | SCN9AFPR2 | |
| SCHEMBL3725438 | 0.78 | SCN9A (0.47) | SCN9AFPR2 | |
| SCHEMBL3723208 | 0.78 | ADORA2B (0.50) | SCN9AFPR2 | |
| SCHEMBL3717581 | 0.76 | PTGS1 (0.56) | SCN9AFPR2 | |
| SCHEMBL3727125 | 0.74 | PTGS2 (0.48) | SCN9AFPR2 | |
| SCHEMBL3727410 | 0.74 | SCN9A (0.53) | SCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |