Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725841 | 1.00 | MAOA (0.56) | MAOAMAOBCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3741806 | 0.77 | ALDH1A1 (0.50) | CYP1A2CYP3A4CYP2C19CYP2C9KDM4E | |
| SCHEMBL3741810 | 0.77 | ALDH1A1 (0.50) | CYP1A2CYP3A4CYP2C19CYP2C9KDM4E | |
| SCHEMBL2470956 | 0.74 | MAOA (0.77) | MAOAMAOBCYP1A2KDM4ELMNA | |
| SCHEMBL275526 | 0.74 | MAOA (0.77) | MAOAMAOBCYP1A2KDM4ELMNA | |
| SCHEMBL29785641 | 0.74 | MAOA (0.77) | MAOAMAOBCYP1A2KDM4ELMNA | |
| SCHEMBL27781079 | 0.73 | MAOA (0.59) | MAOAMAOBCYP2C9KDM4ELMNA | |
| SCHEMBL6747958 | 0.73 | MAOA (0.50) | MAOAMAOBKDM4ELMNAMAPT | |
| SCHEMBL6747962 | 0.73 | MAOA (0.50) | MAOAMAOBKDM4ELMNAMAPT | |
| SCHEMBL670019 | 0.73 | MAOA (1.00) | MAOAMAOBKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825279-B2 | Fused ring dicationic anti-protozoan agents and their prodrugs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-11-02 | — | — | US | claimed |
| US-20050165044-A1 | Fused ring dicationic anti-protozoan agents and their prodrugs | BOYKIN DAVID W (US) | 2005-07-28 | — | — | US | claimed |
| US-7825279-B2 | Fused ring dicationic anti-protozoan agents and their prodrugs | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-11-02 | — | — | US | disclosed |
| EP-1689705-A4 | FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS | UNIV NORTH CAROLINA (US) | 2007-08-29 | — | — | EP | disclosed |
| EP-1689705-A2 | FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20050165044-A1 | Fused ring dicationic anti-protozoan agents and their prodrugs | BOYKIN DAVID W (US) | 2005-07-28 | — | — | US | disclosed |
| WO-2005051296-A2 | FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165044-A1 | Fused ring dicationic anti-protozoan agents and their prodrugs | DHODH, DHFR, PAICS | MAOA 4456/4885MAOB 3612/4885CYP1A2 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.