Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728527 | 0.93 | MEN1 (0.42) | MEN1MAPK1KMT2AP2RX7BDKRB1 | |
| SCHEMBL13165634 | 0.92 | MEN1 (0.44) | MEN1MAPK1KMT2AP2RX7BDKRB1 | |
| SCHEMBL3721990 | 0.90 | BDKRB1 (0.37) | P2RX7BDKRB1EPHX2PDE4BNPC1 | |
| SCHEMBL3728281 | 0.88 | P2RX7 (0.38) | P2RX7BDKRB1EPHX2PDE4BCNR2 | |
| SCHEMBL13191712 | 0.88 | BDKRB1 (0.38) | P2RX7BDKRB1EPHX2PDE4BCNR2 | |
| SCHEMBL13165648 | 0.87 | KMT2A (0.43) | MEN1MAPK1KMT2AP2RX7BDKRB1 | |
| SCHEMBL13191711 | 0.87 | P2RX7 (0.37) | KMT2AP2RX7EPHX2PDE4BCNR2 | |
| SCHEMBL3722075 | 0.87 | P2RX7 (0.37) | KMT2AP2RX7BDKRB1EPHX2PDE4B | |
| SCHEMBL3725869 | 0.85 | MEN1 (0.42) | MEN1MAPK1KMT2ABDKRB1MGAT2 | |
| SCHEMBL3722055 | 0.85 | P2RX7 (0.35) | KMT2AP2RX7MGAT2EPHX2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |