Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 6/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 8/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722078 | 0.93 | BDKRB1 (0.40) | BDKRB1P2RX7CNR1 | |
| SCHEMBL3725868 | 0.90 | MEN1 (0.41) | BDKRB1P2RX7NPC1RAB9AEPHX2 | |
| SCHEMBL3728281 | 0.87 | P2RX7 (0.38) | BDKRB1P2RX7CNR1EPHX2PDE4B | |
| SCHEMBL13191712 | 0.86 | BDKRB1 (0.38) | BDKRB1P2RX7EPHX2PDE4B | |
| SCHEMBL3721992 | 0.86 | BDKRB1 (0.35) | BDKRB1CNR1TP53 | |
| SCHEMBL3722075 | 0.85 | P2RX7 (0.37) | BDKRB1P2RX7EPHX2PDE4B | |
| SCHEMBL13191711 | 0.85 | P2RX7 (0.37) | P2RX7EPHX2PDE4BTP53 | |
| SCHEMBL765813 | 0.84 | CNR1 (0.42) | BDKRB1CNR1 | |
| SCHEMBL13191393 | 0.84 | BDKRB1 (0.41) | BDKRB1CNR1 | |
| SCHEMBL3722055 | 0.83 | P2RX7 (0.35) | P2RX7EPHX2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |