Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3011293 | 0.94 | MAPT (0.53) | MAPTKDM4EHSD17B10GAAALOX15 | |
| SCHEMBL3005567 | 0.84 | CHUK (0.45) | MAPTFBP1POLBL3MBTL1MEN1 | |
| SCHEMBL3008812 | 0.77 | KMT2A (0.41) | MAPTKDM4EHSD17B10GAAALOX15 | |
| SCHEMBL3000240 | 0.74 | ALDH1A1 (0.42) | MAPTKDM4EHSD17B10GAAALOX15 | |
| SCHEMBL3011607 | 0.73 | MAPT (0.49) | MAPTKDM4EHSD17B10GAAALOX15 | |
| SCHEMBL29185296 | 0.69 | FBP1 (0.53) | MAPTALDH1A1FBP1L3MBTL1 | |
| SCHEMBL30182889 | 0.68 | FBP1 (0.36) | ALDH1A1FBP1SMN1; SMN2POLBLMNA | |
| SCHEMBL3005170 | 0.66 | MAPT (0.45) | MAPTKDM4EHSD17B10ALDH1A1FBP1 | |
| SCHEMBL27814575 | 0.65 | ALDH1A1 (0.64) | MAPTGAAALDH1A1HTTCYP2C19 | |
| SCHEMBL3006119 | 0.64 | MAPT (0.41) | MAPTKDM4EHSD17B10GAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |