Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6227307 | 0.78 | NPSR1 (0.55) | NPSR1HIF1ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14854700 | 0.77 | KMT2A (0.37) | NPSR1HIF1AKDM4ETDP1POLB | |
| SCHEMBL989858 | 0.75 | AOC3 (0.55) | CYP2C19CYP1A2TDP1TAAR1 | |
| SCHEMBL31612496 | 0.74 | NPSR1 (1.00) | NPSR1HIF1ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL15489522 | 0.73 | CYP2C19 (0.55) | NPSR1CYP2C19TDP1ALDH1A1MAPT | |
| SCHEMBL7355640 | 0.73 | NPSR1 (0.64) | NPSR1HIF1ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10501002 | 0.72 | HRH1 (0.52) | NPSR1CYP2D6CYP2C9CYP2C19RECQL | |
| SCHEMBL14433130 | 0.72 | HRH1 (0.52) | NPSR1CYP2D6CYP2C9CYP2C19RECQL | |
| SCHEMBL229256 | 0.72 | KDM4E (0.58) | NPSR1CYP2D6CYP2C9CYP2C19RECQL | |
| SCHEMBL31059181 | 0.72 | KDM4E (0.68) | NPSR1HIF1ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137215-A1 | NOVEL TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES | CONCERT PHARMACEUTICALS INC. | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137215-A1 | NOVEL TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES | HTR6, TPH1, HNMT | NPSR1 239/4885HIF1A 3677/4885CYP2D6 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.