Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19145473 | 0.85 | SMN1; SMN2 (0.43) | ALDH1A1HSD17B10KMT2AMEN1LMNA | |
| SCHEMBL902129 | 0.84 | KMT2A (0.34) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL3728129 | 0.80 | CA12 (0.38) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL13123939 | 0.74 | ALDH1A1 (0.44) | ALDH1A1HSD17B10PKMCA12CA1 | |
| SCHEMBL3722406 | 0.70 | LMNA (0.42) | ALDH1A1HSD17B10PKMCA12CA1 | |
| SCHEMBL13123919 | 0.70 | ALDH1A1 (0.44) | ALDH1A1HSD17B10PKMCA12CA1 | |
| SCHEMBL15604720 | 0.70 | LMNA (0.42) | ALDH1A1HSD17B10PKMCA12CA1 | |
| SCHEMBL902866 | 0.66 | LMNA (0.36) | ALDH1A1PKMCA12CA1CA2 | |
| SCHEMBL11125672 | 0.64 | ALDH1A1 (0.51) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL3727257 | 0.63 | ALDH1A1 (0.41) | ALDH1A1HSD17B10PKMKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865684-B2 | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-10-21 | — | — | US | claimed |
| US-20100273743-A1 | MORPHOLIN-4-IUM 4 METHOXYPHENYL (MORPHOLINO) PHOSPHINODITHIOATE (GYY4137) AS A NOVEL VASODILATOR AGENT | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-10-28 | — | — | US | claimed |
| US-9504701-B2 | Methods for treating viral infections using hydrogen sulfide donors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160058779-A1 | METHODS FOR TREATING VIRAL INFECTIONS USING HYDROGEN SULFIDE DONORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-03-03 | — | — | US | disclosed |
| US-8865684-B2 | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-10-21 | — | — | US | disclosed |
| US-8541396-B2 | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-09-24 | — | — | US | disclosed |
| US-20100273743-A1 | MORPHOLIN-4-IUM 4 METHOXYPHENYL (MORPHOLINO) PHOSPHINODITHIOATE (GYY4137) AS A NOVEL VASODILATOR AGENT | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273743-A1 | MORPHOLIN-4-IUM 4 METHOXYPHENYL (MORPHOLINO) PHOSPHINODITHIOATE (GYY4137) AS A NOVEL VASODILATOR AGENT | PDE3B, VASP, PDE3A | ALDH1A1 2809/4885HSD17B10 3807/4885PKM 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.