Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15304182 | 0.82 | ALDH1A1 (0.36) | HRH3GRNSORT1IDO1ALDH1A1 | |
| SCHEMBL24919732 | 0.82 | ALDH1A1 (0.36) | HRH3GRNSORT1IDO1ALDH1A1 | |
| SCHEMBL17327337 | 0.80 | IDO1 (0.43) | TAAR1IDO1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16447921 | 0.80 | IDO1 (0.32) | IDO1LOXL2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20122134 | 0.80 | GRN (0.33) | HRH3GRNSORT1IDO1ALDH1A1 | |
| SCHEMBL26928487 | 0.80 | GRN (0.36) | HRH3GRNSORT1IDO1ALDH1A1 | |
| SCHEMBL22604954 | 0.78 | TAAR1 (0.41) | TAAR1HRH3HRH4 | |
| SCHEMBL22601334 | 0.78 | ACHE (0.33) | HRH3GRNSORT1IDO1ALDH1A1 | |
| SCHEMBL22838143 | 0.77 | TAAR1 (0.44) | TAAR1GRNSORT1ALDH1A1HTT | |
| SCHEMBL28802900 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |