Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724689 | 0.85 | MEN1 (0.50) | ADORA1ADORA3HSD17B10KDM4EALDH1A1 | |
| SCHEMBL3721091 | 0.81 | MEN1 (0.57) | HSD17B10KDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL3719607 | 0.81 | ALDH1A1 (0.50) | HSD17B10KDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL3725556 | 0.80 | ABCB1 (0.56) | ADORA1ADORA3HSD17B10KDM4EALDH1A1 | |
| SCHEMBL3718806 | 0.79 | KDM4E (0.49) | ADORA1ADORA3HSD17B10KDM4EALDH1A1 | |
| SCHEMBL3719736 | 0.78 | NPC1 (0.45) | ADORA1ADORA3HSD17B10KDM4EALDH1A1 | |
| SCHEMBL3451507 | 0.73 | ADORA1 (0.60) | ADORA1ADORA3HSD17B10KDM4EALDH1A1 | |
| SCHEMBL10201961 | 0.72 | MAPT (0.54) | LMNAMAPT | |
| SCHEMBL3720812 | 0.72 | LMNA (0.59) | HSD17B10KDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL3723229 | 0.69 | ADORA1 (0.48) | ADORA1ADORA3HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |