Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801717 | 0.87 | HDAC1 (0.65) | HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL5579422 | 0.75 | AVPR1A (0.51) | RIPK1PTGDR2 | |
| SCHEMBL12847329 | 0.74 | SIGMAR1 (0.52) | HDAC1HDAC6SIGMAR1 | |
| SCHEMBL4068492 | 0.73 | RIPK1 (0.64) | HDAC1HDAC6HDAC8RIPK1CHRM2 | |
| SCHEMBL25358257 | 0.73 | NOTUM (0.61) | HDAC1HDAC6HDAC8NOTUM | |
| SCHEMBL23211956 | 0.71 | NOTUM (0.51) | NOTUM | |
| SCHEMBL14791762 | 0.70 | SIGMAR1 (0.45) | HDAC1HDAC6HDAC8NOTUMSIGMAR1 | |
| SCHEMBL17771693 | 0.70 | SIGMAR1 (0.55) | HDAC1HDAC6HDAC8SIGMAR1 | |
| SCHEMBL28975113 | 0.69 | HDAC1 (0.51) | HDAC1HDAC6HDAC8 | |
| SCHEMBL12847641 | 0.69 | NOTUM (0.47) | HDAC1HDAC6PTGDR2NOTUMSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240483-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089454-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |