Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.62 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728319 | 0.87 | HDAC1 (0.52) | HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL25239319 | 0.80 | HDAC1 (0.67) | HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL4068492 | 0.78 | RIPK1 (0.64) | HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL23289929 | 0.76 | HDAC1 (0.64) | HDAC1HDAC6HDAC8 | |
| SCHEMBL5578574 | 0.76 | HDAC1 (0.51) | HDAC1HDAC6HDAC8NPY5RTACR1 | |
| SCHEMBL1223510 | 0.76 | NOTUM (0.76) | HDAC1HDAC6NPY5R | |
| SCHEMBL13228096 | 0.75 | HDAC1 (0.68) | HDAC1HDAC6HDAC8TACR1 | |
| SCHEMBL13227805 | 0.75 | HDAC1 (0.64) | HDAC1HDAC6HDAC8NPY5R | |
| SCHEMBL1587044 | 0.75 | NPY5R (0.44) | NPY5R | |
| SCHEMBL13228108 | 0.75 | HDAC1 (0.61) | HDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206714-B1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8729264-B2 | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2206714-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | Kyowa Hakko Kirin Co., Ltd. (JP) | 2010-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | TYR, CUTA, SERPINB1 | HDAC1 607/4885HDAC6 503/4885HDAC8 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.