Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HMGCR | P04035 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329618 | 0.87 | CYP2D6 (0.42) | TDP1CYP2D6TSHRCYP2C19HIF1A | |
| Propylene Glycol SCHEMBL3731405 | 0.86 | HSD17B10 (0.33) | TDP1CYP2D6TSHRCYP2C19HIF1A | |
| SCHEMBL3731850 | 0.86 | TDP1 (0.35) | TDP1 | |
| Ethylene Glycol SCHEMBL3734256 | 0.85 | CYP2D6 (0.38) | TDP1CYP2D6TSHRCYP2C19HIF1A | |
| Propylene Glycol SCHEMBL3739761 | 0.83 | HSPD1 (0.35) | TDP1ALDH1A1 | |
| 1,4-Butanediol SCHEMBL3728797 | 0.81 | CYP4F2 (0.37) | TDP1CYP2D6TSHRCYP2C19HIF1A | |
| Propylene Glycol SCHEMBL3730785 | 0.81 | TDP1 (0.39) | TDP1CYP2D6TSHRCYP2C19HIF1A | |
| SCHEMBL5346342 | 0.79 | CYP2D6 (0.39) | TDP1CYP2D6TSHRCYP2C19HIF1A | |
| SCHEMBL315985 | 0.79 | CYP2D6 (0.39) | TDP1CYP2D6TSHRCYP2C19HIF1A | |
| Di(Hydroxyethyl)Ether SCHEMBL3736317 | 0.79 | ALDH1A1 (0.40) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |