Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315985 | 1.00 | CYP2D6 (0.39) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| SCHEMBL4329618 | 0.91 | CYP2D6 (0.42) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| SCHEMBL3258251 | 0.86 | SOAT1 (0.36) | TSHRALDH1A1MEN1CYP1A2THRB | |
| Ethylene Glycol SCHEMBL3734256 | 0.85 | CYP2D6 (0.38) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| SCHEMBL28324952 | 0.84 | SOAT1 (0.35) | ALDH1A1MEN1CYP1A2THRBKMT2A | |
| 1,4-Butanediol SCHEMBL3728797 | 0.82 | CYP4F2 (0.37) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| Propylene Glycol SCHEMBL3728972 | 0.79 | TDP1 (0.36) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL3736317 | 0.79 | ALDH1A1 (0.40) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| SCHEMBL8068518 | 0.78 | CYP2C19 (0.44) | CYP2D6TSHRCYP2C19HIF1AALDH1A1 | |
| SCHEMBL1670467 | 0.78 | MEN1 (0.32) | ALDH1A1MEN1CYP1A2THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128789-A1 | Process for the preparation of substituted pyrrolidine derivatives and intermediates | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | US | claimed |
| US-7230119-B2 | Process for the preparation of substituted pyrrolidine derivatives and intermediates | BIOCRYST PHARMACEUTICALS, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-7230119-B2 | Process for the preparation of substituted pyrrolidine derivatives and intermediates | BIOCRYST PHARMACEUTICALS, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060128789-A1 | Process for the preparation of substituted pyrrolidine derivatives and intermediates | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | US | disclosed |
| US-20060128789-A1 | Process for the preparation of substituted pyrrolidine derivatives and intermediates | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128789-A1 | Process for the preparation of substituted pyrrolidine derivatives and intermediates | PNISR, PNMT, GRHPR | CYP2D6 1159/4885TSHR 315/4885CYP2C19 1411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.