Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726023 | 0.85 | MET (0.68) | METCYP3A4 | |
| SCHEMBL3719800 | 0.83 | MET (0.61) | METCYP3A4HTTKCNH2 | |
| SCHEMBL3723300 | 0.81 | MET (0.62) | METCYP3A4HTTKCNH2 | |
| SCHEMBL3726496 | 0.77 | MET (0.66) | METCYP3A4HTTKCNH2 | |
| SCHEMBL3720032 | 0.76 | ALDH1A1 (0.56) | METCYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL3726799 | 0.76 | MET (0.59) | METCYP3A4 | |
| SCHEMBL2764542 | 0.74 | MET (0.64) | METCYP3A4KDM4EHPGDKCNH2 | |
| SCHEMBL3719085 | 0.74 | MET (0.57) | METCYP3A4KCNH2 | |
| SCHEMBL3800032 | 0.74 | MET (1.00) | METCYP3A4 | |
| SCHEMBL3802800 | 0.74 | MET (1.00) | METCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393791-A1 | DERIVATIVES OF 6-(6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI (FR) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089507-A1 | DERIVATIVES OF 6-(6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2010-08-12 | — | — | WO | disclosed |