Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14832703 | 0.81 | PDE4B (0.49) | ALDH1A1KDM4EHPGDHTTCYP3A4 | |
| SCHEMBL3729185 | 0.76 | MET (0.59) | ALDH1A1KDM4EHPGDHTTMET | |
| SCHEMBL18596494 | 0.74 | L3MBTL1 (0.67) | ALDH1A1KDM4EHPGDHTTLMNA | |
| SCHEMBL16439068 | 0.74 | L3MBTL1 (0.48) | ALDH1A1KDM4EHTTLMNACYP3A4 | |
| SCHEMBL16428752 | 0.73 | SLC2A1 (0.39) | KDM4EL3MBTL1 | |
| SCHEMBL17099378 | 0.73 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL14832474 | 0.73 | LRRK2 (0.56) | ALDH1A1KDM4EHPGDHTTBRD4 | |
| SCHEMBL14832950 | 0.72 | LRRK2 (0.49) | ALDH1A1KDM4EHPGDHTTLMNA | |
| SCHEMBL14832883 | 0.71 | SMN1; SMN2 (0.50) | ALDH1A1KDM4EHPGDHTTLMNA | |
| SCHEMBL16439060 | 0.71 | LRRK2 (0.69) | ALDH1A1KDM4EHPGDCYP3A4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393791-A1 | DERIVATIVES OF 6-(6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI (FR) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089507-A1 | DERIVATIVES OF 6-(6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2010-08-12 | — | — | WO | disclosed |