Citric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ACVR1 ADORA1 ADORA2A ADORA2B ADORA3 ESR1 ESR2 FLT3 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GSC1 HRH1 HTR7 IDH1 IDH2 IRAK1 JAK1 JAK2 JAK3 MEN1 OPRM1 P2RX3 PDE5A SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SIGMAR1 SLC6A2 SYK TACR1 TOP2A TYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	HTR7 known ✓	P34969	1/20	0.54

▸	ADORA2B known ✓	P29275	5/20	0.48

▸	HTR6	P50406	1/20	0.54

▸	TSHR	P16473	2/20	0.51

▸	L3MBTL1	Q9Y468	2/20	0.50

▸	RXFP1	Q9HBX9	4/20	0.48

▸	SMN1; SMN2	Q16637	1/20	0.48

▸	ALDH1A1	P00352	1/20	0.47

▸	MAPK1	P28482	1/20	0.47

▸	TP53	P04637	1/20	0.46

▸	HTR1A	P08908	2/20	0.46

▸	ADRA1D	P25100	2/20	0.46

▸	ADRA1A	P35348	2/20	0.46

▸	ADRA1B	P35368	2/20	0.46

▸	CHRM2	P08172	1/20	0.46

▸	CHRM1	P11229	1/20	0.46

▸	DRD2	P14416	1/20	0.46

▸	KMT2A	Q03164	1/20	0.45

▸	MAPT	P10636	1/20	0.43

▸	LMNA	P02545	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL458792	0.89	HTR7 (0.63)	HTR7HTR6TSHRL3MBTL1ADORA2B
SCHEMBL29375465	0.89	HTR7 (0.63)	HTR7HTR6TSHRL3MBTL1ADORA2B
Ammonia Solution, Strong SCHEMBL12804036	0.88	HTR7 (0.62)	HTR7HTR6TSHRL3MBTL1ADORA2B
Hydrochloric Acid SCHEMBL2290149	0.88	HTR7 (0.65)	HTR7HTR6TSHRL3MBTL1ADORA2B
SCHEMBL11152654	0.83	HTR7 (0.73)	HTR7HTR6TSHRL3MBTL1ADORA2B
SCHEMBL11152582	0.82	HTR7 (0.74)	HTR7HTR6TSHRL3MBTL1ADORA2B
SCHEMBL684356	0.81	HTR7 (0.58)	HTR7HTR6TSHRL3MBTL1ADORA2B
SCHEMBL2626922	0.79	HTR7 (0.63)	HTR7HTR6TSHRL3MBTL1ADORA2B
SCHEMBL4401766	0.79	HTR7 (0.62)	HTR7HTR6TSHRL3MBTL1ADORA2B
SCHEMBL4399057	0.79	TSHR (0.72)	HTR7HTR6TSHRL3MBTL1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20100280041-A1	RHOKINASE-DEPENDENT INHIBITION ACTIVITY ON PULMONARY ARTERY ENDOTHELIUM DYSFUNCTION, MEDIAL WALL THICKNESS AND VASCULAR OBSTRUCTION OF PULMODIL AND PULMODIL-1	KAOHSIUNG MEDICAL UNIVERSITY (TW)	2010-11-04	—	—	US	claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20100280041-A1	RHOKINASE-DEPENDENT INHIBITION ACTIVITY ON PULMONARY ARTERY ENDOTHELIUM DYSFUNCTION, MEDIAL WALL THICKNESS AND VASCULAR OBSTRUCTION OF PULMODIL AND PULMODIL-1	ROCK1, MYLK, PTGIR	HTR7 3815/4885ADORA2B 2518/4885HTR6 4222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.