Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3732444 | 1.00 | DRD2 (0.38) | DRD2DRD3ALOX5APFEN1SCN9A | |
| SCHEMBL3725607 | 0.81 | JUN (0.39) | SCN9A | |
| SCHEMBL840182 | 0.77 | DRD2 (0.50) | DRD2DRD3 | |
| SCHEMBL841287 | 0.77 | DRD2 (0.50) | DRD2DRD3 | |
| SCHEMBL14781413 | 0.77 | DRD2 (0.50) | DRD2DRD3 | |
| Ammonia Solution, Strong SCHEMBL3729586 | 0.76 | DRD2 (0.49) | DRD2DRD3 | |
| Ammonia Solution, Strong SCHEMBL3732439 | 0.76 | DRD2 (0.49) | DRD2DRD3 | |
| SCHEMBL3727066 | 0.76 | ANPEP (0.36) | — | |
| SCHEMBL3737203 | 0.75 | CYP19A1 (0.39) | — | |
| SCHEMBL3732400 | 0.69 | DRD2 (0.34) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |