Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 11/20 | 0.86 |
| ▸ | MAPT | P10636 | 3/20 | 0.86 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.86 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.86 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.86 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.86 |
| ▸ | GC | P02774 | 1/20 | 0.86 |
| ▸ | PGR | P06401 | 1/20 | 0.86 |
| ▸ | RXRA | P19793 | 1/20 | 0.86 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.86 |
| ▸ | CNR1 | P21554 | 1/20 | 0.86 |
| ▸ | HTR2C | P28335 | 1/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.86 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.86 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.86 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.86 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.86 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9722585 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL10445242 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL9722601 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL11165113 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL10892411 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL10895773 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL23359068 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL9722594 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL9173699 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 | |
| SCHEMBL9722605 | 1.00 | VDR (0.86) | VDRMAPTADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401357-B1 | IMPROVING REPRODUCTIVE FUNCTIONS IN MAMMALS | WISCONSIN ALUMNI RES FOUND (US) | 1996-03-20 | — | — | EP | claimed |
| EP-0207451-B1 | PHARMACEUTICAL PREPARATIONS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-18 | — | — | EP | claimed |
| EP-0401357-A1 | METHOD FOR IMPROVING REPRODUCTIVE FUNCTIONS IN MAMMALS. | WISCONSIN ALUMNI RES FOUND (US) | 1990-12-12 | — | — | EP | claimed |
| EP-0207451-A2 | Pharmaceutical preparations | F. HOFFMANN-LA ROCHE AG (CH) | 1987-01-07 | — | — | EP | claimed |
| EP-0086476-B1 | UTILIZATION OF CHOLECALCIFEROL DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-05-07 | — | — | EP | claimed |
| EP-0086476-A2 | Utilization of cholecalciferol derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-08-24 | — | — | EP | claimed |
| JP-8103227-A | — | — | None | — | — | JP | disclosed |
| JP-58210017-A | — | — | None | — | — | JP | disclosed |
| EP-2190422-A1 | A METHOD OF EXTENDING THE DOSE RANGE OF VITAMIN D COMPOUNDS | Wisconsin Alumni Research Foundation (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026265-A1 | A METHOD OF EXTENDING THE DOSE RANGE OF VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-02-26 | — | — | WO | disclosed |
| US-20080249068-A1 | Method of Extending the Dose Range of Vitamin D Compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-10-09 | — | — | US | disclosed |
| US-7259143-B2 | Method of extending the dose range of vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1545549-A1 | A METHOD OF EXTENDING THE DOSE RANGE OF VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2005-06-29 | — | — | EP | disclosed |
| JP-S58210017-A | ANTITUMOR AGENT | KUREHA CHEM IND CO LTD | 1983-12-07 | — | — | JP | disclosed |
| US-4407754-A | Cholecalciferol derivatives | HOFFMANN-LA ROCHE INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4407754-A | Cholecalciferol derivatives | HOFFMANN-LA ROCHE INC. (US) | 1983-10-04 | — | — | US | disclosed |
| EP-0086476-A2 | Utilization of cholecalciferol derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-08-24 | — | — | EP | disclosed |
| EP-0077353-A1 | 1-HYDROXYLATION PROCESS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1983-04-27 | — | — | EP | disclosed |
| WO-1982003864-A1 | 1-HYDROXYLATION PROCESS | WISCONSIN ALUMNI RES FOUND (US) | 1982-11-11 | — | — | WO | disclosed |
| US-4225525-A | Vitamin D3 metabolite derivatives | HOFFMANN-LA ROCHE INC. (US) | 1980-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249068-A1 | Method of Extending the Dose Range of Vitamin D Compounds | VDR, CASK, CYP24A1 | VDR 1/4885MAPT 3703/4885ADORA3 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.