Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722568 | 0.84 | LMNA (0.49) | LMNAALDH1A1RXFP1DRD2DRD3 | |
| SCHEMBL3723647 | 0.83 | GRM5 (0.47) | GRM5LMNAALDH1A1RXFP1DRD2 | |
| SCHEMBL3109950 | 0.80 | GRM5 (0.57) | GRM5LMNAALDH1A1RXFP1DRD2 | |
| SCHEMBL3109955 | 0.80 | GRM5 (0.57) | GRM5LMNAALDH1A1RXFP1DRD2 | |
| SCHEMBL2919979 | 0.79 | GRM5 (0.47) | GRM5LMNAALDH1A1RXFP1DRD2 | |
| SCHEMBL3724363 | 0.75 | DRD2 (0.43) | GRM5LMNAALDH1A1RXFP1DRD2 | |
| SCHEMBL23465973 | 0.74 | NPC1 (0.62) | LMNAALDH1A1DRD2DRD3KCNH2 | |
| SCHEMBL17712940 | 0.73 | DRD2 (0.53) | LMNAALDH1A1DRD2DRD3KCNH2 | |
| SCHEMBL4089356 | 0.72 | GRM5 (0.56) | GRM5LMNAALDH1A1KMT2AMAPT | |
| SCHEMBL3109098 | 0.71 | GRM5 (0.59) | GRM5LMNAALDH1A1RXFP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123451-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | WO | claimed |