SCHEMBL373234

SCHEMBL373234

C=C(C)C(=O)Oc1cc2ccccc2c(N=Nc2cccc3ccccc23)c1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 5/20 0.48
▸ ALDH1A1 P00352 4/20 0.48
▸ HIF1A Q16665 3/20 0.48
▸ CYP2C9 P11712 2/20 0.45
▸ TSHR P16473 1/20 0.45
▸ PTPRA P18433 1/20 0.45
▸ PTPRB P23467 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ RAPGEF4 Q8WZA2 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45
▸ MAPK1 P28482 4/20 0.42
▸ DNASE1L3 Q13609 1/20 0.42
▸ SENP2 Q9HC62 1/20 0.39
▸ SENP1 Q9P0U3 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ PTPN11 Q06124 1/20 0.39
▸ PRMT1 Q99873 1/20 0.38
▸ KDM4E B2RXH2 3/20 0.37
▸ MAPT P10636 3/20 0.37
▸ NPC1 O15118 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7179285 1.00 CYP1A2 (0.48) CYP1A2ALDH1A1HIF1ACYP2C9TSHR
SCHEMBL373500 0.93 CYP1A2 (0.42) CYP1A2ALDH1A1HIF1ACYP2C9TSHR
SCHEMBL718829 0.86 MAPT (0.47) CYP1A2ALDH1A1HIF1AMAPK1PRMT1
SCHEMBL1802886 0.86 MAPT (0.47) CYP1A2ALDH1A1HIF1AMAPK1PRMT1
SCHEMBL373229 0.86 MAPT (0.47) CYP1A2ALDH1A1HIF1AMAPK1PRMT1
SCHEMBL373328 0.86 MAPT (0.47) CYP1A2ALDH1A1HIF1AMAPK1PRMT1
SCHEMBL13609825 0.85 CYP1A2 (0.43) CYP1A2ALDH1A1HIF1ACYP2C9TSHR
SCHEMBL7179907 0.84 CYP1A2 (0.48) CYP1A2ALDH1A1HIF1ACYP2C9TSHR
SCHEMBL7179903 0.84 CYP1A2 (0.48) CYP1A2ALDH1A1HIF1ACYP2C9TSHR
SCHEMBL7178612 0.77 CYP1A2 (0.42) CYP1A2ALDH1A1HIF1ACYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 — — US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 — — EP disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 — — EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 — — US disclosed
EP-3086163-B1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME MENICON CO LTD (JP) 2018-11-14 — — EP disclosed
EP-2857459-B1 STABLE POLYMERIZABLE UV-ABSORBING COLORANT FOR INTRAOCULAR LENS KOWA CO (JP) 2017-12-27 — — EP disclosed
US-9657131-B2 Ophthalmic lens MENICON CO., LTD. (JP) 2017-05-23 — — US disclosed
US-9650473-B2 Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same MENICON CO., LTD. (JP) 2017-05-16 — — US disclosed
EP-2330161-B1 DYE COMPOSITION FOR OPHTHALMIC LENS, METHOD FOR PRODUCING COLORED OPHTHALMIC LENS USING THE SAME AND COLORED OPHTHALMIC LENS MENICON CO LTD (JP) 2017-01-25 — — EP disclosed
EP-3086163-A1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME Menicon Co., Ltd. (JP) 2016-10-26 — — EP disclosed
US-5416180-A Fluorine containing (meth)acrylate polymers MENICON CO., LTD. (JP) 1995-05-16 — — US disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 — — US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 — — EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 — — US disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 — — EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 — — EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 — — EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 — — US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 — — US disclosed
EP-0379146-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1990-07-25 — — EP disclosed
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