SCHEMBL373229

SCHEMBL373229

C=C(C)C(=O)Oc1cc2ccccc2c(N=Nc2ccc(N=Nc3ccccc3)cc2)c1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 9/20 0.47
▸ MEN1 O00255 7/20 0.47
▸ KMT2A Q03164 7/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ L3MBTL1 Q9Y468 4/20 0.47
▸ POLB P06746 3/20 0.47
▸ MAPK1 P28482 3/20 0.47
▸ RECQL P46063 2/20 0.47
▸ NPC1 O15118 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ IDO1 P14902 1/20 0.47
▸ CASP6 P55212 1/20 0.47
▸ CTDSP1 Q9GZU7 1/20 0.47
▸ TDP1 Q9NUW8 3/20 0.46
▸ MITF O75030 1/20 0.46
▸ USP2 O75604 1/20 0.46
▸ THRB P10828 3/20 0.45
▸ NQO2 P16083 1/20 0.42
▸ PKM P14618 2/20 0.41
▸ CASP3 P42574 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1802886 1.00 MAPT (0.47) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL373328 1.00 MAPT (0.47) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL718829 1.00 MAPT (0.47) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL626265 0.86 KMT2A (0.52) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL7179285 0.86 CYP1A2 (0.48) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL373234 0.86 CYP1A2 (0.48) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL13609833 0.85 THRB (0.50) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL7830817 0.85 MEN1 (0.41) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL373500 0.84 CYP1A2 (0.42) MAPTMEN1KMT2AALDH1A1L3MBTL1
SCHEMBL13609828 0.84 THRB (0.51) MAPTMEN1KMT2AALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 — — EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 — — US disclosed
EP-3086163-B1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME MENICON CO LTD (JP) 2018-11-14 — — EP disclosed
US-9657131-B2 Ophthalmic lens MENICON CO., LTD. (JP) 2017-05-23 — — US disclosed
US-9650473-B2 Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same MENICON CO., LTD. (JP) 2017-05-16 — — US disclosed
EP-2330161-B1 DYE COMPOSITION FOR OPHTHALMIC LENS, METHOD FOR PRODUCING COLORED OPHTHALMIC LENS USING THE SAME AND COLORED OPHTHALMIC LENS MENICON CO LTD (JP) 2017-01-25 — — EP disclosed
EP-3086163-A1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME Menicon Co., Ltd. (JP) 2016-10-26 — — EP disclosed
EP-3086162-A1 OCULAR LENS Menicon Co., Ltd. (JP) 2016-10-26 — — EP disclosed
US-20160289368-A1 OPHTHALMIC LENS MENICON CO., LTD. (JP) 2016-10-06 — — US disclosed
US-20160272766-A1 POLYSILOXANE-BASED MACROMONOMER FOR OPHTHALMIC LENS AND OPHTHALMIC LENS USING THE SAME MENICON CO., LTD. (JP) 2016-09-22 — — US disclosed
US-5416180-A Fluorine containing (meth)acrylate polymers MENICON CO., LTD. (JP) 1995-05-16 — — US disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 — — US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 — — EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 — — US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 — — EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 — — EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 — — EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 — — EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 — — US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 — — US disclosed
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