Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | DAO | P14920 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17204107 | 0.88 | CES2 (0.50) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL3181932 | 0.87 | CES2 (0.58) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL15120382 | 0.85 | CES2 (0.56) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL5394296 | 0.82 | CES2 (0.62) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL3196141 | 0.80 | TSHR (0.51) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL2173910 | 0.79 | TSHR (0.50) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL7351527 | 0.79 | CES2 (0.48) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL9367334 | 0.79 | DAO (0.52) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL11495009 | 0.78 | CES2 (0.58) | CES2CES1DAOTSHRNPC1 | |
| SCHEMBL7037574 | 0.78 | CES2 (0.58) | CES2CES1DAOTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456295-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-11-25 | — | — | US | claimed |
| US-9051401-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2015-06-09 | — | — | US | disclosed |
| US-8680292-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2014-03-25 | — | — | US | disclosed |
| US-8183390-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-22 | — | — | US | disclosed |
| US-7829660-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2010-11-09 | — | — | US | disclosed |
| US-7829660-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2010-11-09 | — | — | US | disclosed |
| US-7829660-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2010-11-09 | — | — | US | disclosed |
| US-7608179-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608179-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608179-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7456295-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456295-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456295-B1 | Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-11-25 | — | — | US | disclosed |