Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3196141 | 0.84 | TSHR (0.51) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL22955796 | 0.81 | TSHR (0.49) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL1925969 | 0.79 | TSHR (0.47) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL3181932 | 0.79 | CES2 (0.58) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL3732383 | 0.79 | CES2 (0.58) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL15120382 | 0.77 | CES2 (0.56) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL17204107 | 0.76 | CES2 (0.50) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL31388183 | 0.76 | TSHR (0.44) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL7037574 | 0.75 | CES2 (0.58) | TSHRRAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL1760911 | 0.75 | CES1 (0.58) | TSHRRAB9AALDH1A1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501967-B2 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2013-08-06 | — | — | US | disclosed |
| US-20120316350-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2012-12-13 | — | — | US | disclosed |
| US-8258338-B2 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2012-09-04 | — | — | US | disclosed |
| EP-1720852-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2012-07-11 | — | — | EP | disclosed |
| US-8193380-B2 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2012-06-05 | — | — | US | disclosed |
| US-20110207946-A1 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | LONZA AG (CH) | 2011-08-25 | — | — | US | disclosed |
| US-7973182-B2 | enantiomerically pure 1-substituted-3-amino-alcohols, particularly of (S)-(-)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of the formula: | LONZA LTD. (CH) | 2011-07-05 | — | — | US | disclosed |
| US-20090156833-A1 | Process for the Preparation of Enantiomerically Pure 1-Substituted-3-Aminoalcohols | LONZA AG (CH) | 2009-06-18 | — | — | US | disclosed |
| US-20080154047-A1 | Process For the Preparation of Enantiomerically Pure1-Substitued-3-Aminoalcohols | LONZA AG (CH) | 2008-06-26 | — | — | US | disclosed |
| EP-1868983-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2007-12-26 | — | — | EP | disclosed |
| EP-1720852-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2006-11-15 | — | — | EP | disclosed |
| WO-2006087166-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2006-08-24 | — | — | WO | disclosed |
| WO-2005080370-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | LONZA AG (CH) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207946-A1 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols | ALDH7A1, BCKDK, AASDHPPT | TSHR 3197/4885RAB9A 3731/4885ALDH1A1 63/4885 |
| US-20120316350-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS | CYP2S1, AKR1C3, AKR1B10 | TSHR 3248/4885RAB9A 2680/4885ALDH1A1 99/4885 |
| US-20090156833-A1 | Process for the Preparation of Enantiomerically Pure 1-Substituted-3-Aminoalcohols | CYP2S1, AKR1C3, ADSL | TSHR 2336/4885RAB9A 2362/4885ALDH1A1 122/4885 |
| US-20080154047-A1 | Process For the Preparation of Enantiomerically Pure1-Substitued-3-Aminoalcohols | ADH1A, ADH1C, ALDH7A1 | TSHR 3042/4885RAB9A 3538/4885ALDH1A1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.