Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12260664 | 0.86 | NPC1 (0.54) | DAOKMT2AMAPTCES2CES1 | |
| SCHEMBL31497793 | 0.83 | DAO (0.48) | DAOHPGDSKMT2AMAPTCES2 | |
| SCHEMBL3732383 | 0.79 | CES2 (0.58) | DAOHPGDSKMT2AMAPTCES2 | |
| SCHEMBL3181932 | 0.79 | CES2 (0.58) | DAOHPGDSKMT2ACES2CES1 | |
| SCHEMBL15120382 | 0.77 | CES2 (0.56) | DAOHPGDSKMT2ACES2CES1 | |
| SCHEMBL5394296 | 0.74 | CES2 (0.62) | DAOHPGDSKMT2ACES2CES1 | |
| SCHEMBL7351536 | 0.74 | DAO (0.50) | DAOHPGDSKMT2AMAPTCES2 | |
| SCHEMBL11701235 | 0.73 | HPGDS (0.62) | DAOHPGDSMAPTCES2CES1 | |
| SCHEMBL3196141 | 0.73 | TSHR (0.51) | DAOHPGDSKMT2AMAPTCES2 | |
| SCHEMBL17204107 | 0.73 | CES2 (0.50) | DAOHPGDSKMT2AMAPTCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346791-B1 | 1,2-diarylethylamines for treatment of neurotoxic injury | SEARLE & CO (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0346791-A1 | 1,2-diarylethylamines for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1989-12-20 | — | — | EP | disclosed |