Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054061 | 0.88 | CYP1A2 (0.41) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1052083 | 0.84 | POLR1A (0.38) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1055040 | 0.84 | POLR1A (0.38) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1054633 | 0.84 | POLR1A (0.38) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1054247 | 0.73 | EPHX1 (0.41) | KMT2APOLBSMN1; SMN2 | |
| SCHEMBL1052583 | 0.73 | KAT2B (0.42) | KMT2APOLBSMN1; SMN2 | |
| SCHEMBL3738350 | 0.72 | KAT2B (0.41) | KMT2APOLBSMN1; SMN2 | |
| SCHEMBL1049828 | 0.71 | HTR4 (0.45) | KCNH2 | |
| SCHEMBL3733975 | 0.70 | CA12 (0.49) | CYP1A2CYP2C19CYP3A4KMT2A | |
| SCHEMBL6436320 | 0.70 | CA12 (0.49) | KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |