Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439086 | 0.86 | SMARCA2 (0.37) | MAPK1GPR119NR1H2USP30 | |
| SCHEMBL28439087 | 0.85 | EGFR (0.36) | MAPK1NR1H2NR1H3USP30 | |
| SCHEMBL27848285 | 0.84 | KDM4E (0.41) | MAPK1KDM4EPKMSIGMAR1GPR119 | |
| SCHEMBL28029544 | 0.84 | MAPK1 (0.39) | MAPK1KDM4EPKMSIGMAR1GPR119 | |
| SCHEMBL27626264 | 0.83 | SIGMAR1 (0.44) | MAPK1SIGMAR1MEN1KMT2AUSP2 | |
| SCHEMBL28670928 | 0.82 | USP2 (0.35) | MAPK1GPR119NR1H2NR1H3USP2 | |
| SCHEMBL5478401 | 0.82 | USP2 (0.35) | MAPK1GPR119NR1H2NR1H3USP2 | |
| SCHEMBL16636874 | 0.82 | USP2 (0.35) | MAPK1GPR119NR1H2NR1H3USP2 | |
| SCHEMBL28975611 | 0.78 | USP2 (0.34) | MAPK1NR1H2USP2 | |
| SCHEMBL4710880 | 0.77 | NR1H2 (0.39) | MAPK1KDM4EPKMGPR119NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170866-A1 | PHTHALAZINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Amgen Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009002469-A1 | PHTHALAZINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | AMGEN INC. (US) | 2008-12-31 | — | — | WO | disclosed |