Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3733138 | 0.84 | MAPK1 (0.39) | MAPK1KDM4EPKMGPR119SIGMAR1 | |
| SCHEMBL27848285 | 0.83 | KDM4E (0.41) | MAPK1KDM4EPKMGPR119SIGMAR1 | |
| SCHEMBL28637688 | 0.81 | NR1H2 (0.40) | MAPK1KDM4EPKMGPR119KDM1A | |
| SCHEMBL4710880 | 0.76 | NR1H2 (0.39) | MAPK1KDM4EPKMGPR119NR1H2 | |
| SCHEMBL30151394 | 0.76 | NR1H2 (0.40) | MAPK1KDM4EPKMGPR119KDM1A | |
| SCHEMBL27696448 | 0.76 | LMNA (0.40) | MAPK1GPR119MEN1KMT2ANR1H2 | |
| SCHEMBL4321471 | 0.75 | STS (0.39) | MAPK1KDM4EPKMGPR119KMT2A | |
| SCHEMBL11093077 | 0.74 | MAPK1 (0.44) | MAPK1KDM4EPKMGPR119MEN1 | |
| SCHEMBL27848384 | 0.74 | GPR119 (0.42) | MAPK1KDM4EPKMGPR119KDM1A | |
| SCHEMBL29129161 | 0.73 | MAPK1 (0.38) | MAPK1KDM4EPKMGPR119KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105229002-A | BET protein inhibiting dihydropyridopyrazinones | Bayer Pharma AG | 2016-01-06 | — | — | CN | disclosed |