SCHEMBL373331

SCHEMBL373331

C=C(C)C(=O)OCCc1ccc(N=Nc2c(O)ccc(C(=O)c3ccccc3)c2O)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
MAPT P10636 6/20 0.36
PPARA Q07869 5/20 0.36
KDM4E B2RXH2 4/20 0.36
ALDH1A1 P00352 4/20 0.36
MEN1 O00255 3/20 0.36
RECQL P46063 3/20 0.36
KMT2A Q03164 3/20 0.36
PPARD Q03181 2/20 0.36
MAPK1 P28482 2/20 0.36
POLB P06746 2/20 0.36
NPC1 O15118 1/20 0.36
IDO1 P14902 1/20 0.36
CASP6 P55212 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
ALOX15 P16050 3/20 0.36
HSD17B10 Q99714 3/20 0.36
ELANE P08246 1/20 0.36
APP P05067 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL373513 0.94 PPARG (0.39) PPARGL3MBTL1MAPTPPARAKDM4E
SCHEMBL3184025 0.92 PPARG (0.35) PPARGL3MBTL1MAPTPPARAKDM4E
SCHEMBL3184031 0.92 PPARG (0.35) PPARGL3MBTL1MAPTPPARAKDM4E
SCHEMBL373839 0.90 ALDH1A1 (0.41) PPARGL3MBTL1MAPTKDM4EALDH1A1
SCHEMBL7174763 0.90 ALDH1A1 (0.41) PPARGL3MBTL1MAPTKDM4EALDH1A1
SCHEMBL16693317 0.88 L3MBTL1 (0.41) PPARGL3MBTL1MAPTPPARAKDM4E
SCHEMBL10430975 0.87 L3MBTL1 (0.43) PPARGL3MBTL1PPARAALDH1A1PPARD
SCHEMBL374000 0.85 MAPT (0.36) L3MBTL1MAPTKDM4EALDH1A1MEN1
SCHEMBL16693261 0.83 L3MBTL1 (0.39) PPARGL3MBTL1MAPTPPARAKDM4E
SCHEMBL373648 0.83 L3MBTL1 (0.39) PPARGL3MBTL1MAPTPPARAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-112703213-A Polymer material 株式会社目立康 2021-04-23 CN disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
EP-3086163-B1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME MENICON CO LTD (JP) 2018-11-14 EP disclosed
EP-2857459-B1 STABLE POLYMERIZABLE UV-ABSORBING COLORANT FOR INTRAOCULAR LENS KOWA CO (JP) 2017-12-27 EP disclosed
US-9657131-B2 Ophthalmic lens MENICON CO., LTD. (JP) 2017-05-23 US disclosed
US-9650473-B2 Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same MENICON CO., LTD. (JP) 2017-05-16 US disclosed
EP-2330161-B1 DYE COMPOSITION FOR OPHTHALMIC LENS, METHOD FOR PRODUCING COLORED OPHTHALMIC LENS USING THE SAME AND COLORED OPHTHALMIC LENS MENICON CO LTD (JP) 2017-01-25 EP disclosed
EP-0379146-B1 Soft ocular lens material MENICON CO LTD (JP) 1995-05-17 EP disclosed
US-5416180-A Fluorine containing (meth)acrylate polymers MENICON CO., LTD. (JP) 1995-05-16 US disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed