Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | P4HB | P07237 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441671 | 0.91 | PTGS2 (0.51) | PTGS2NTSR1CYP1A1CYP1B1SNCA | |
| SCHEMBL3735482 | 0.91 | PTGS2 (0.51) | PTGS2NTSR1CYP1A1CYP1B1SNCA | |
| SCHEMBL3734081 | 0.90 | CYP1A1 (0.47) | PTGS2NTSR1CYP1A1CYP1B1SNCA | |
| SCHEMBL3738227 | 0.87 | PTGS2 (0.47) | PTGS2CYP1A1CYP1B1TRPV1MAOB | |
| SCHEMBL3735031 | 0.85 | ABCG2 (0.53) | CYP1A1CYP1B1CYP1A2MAPTTNFRSF1A | |
| SCHEMBL3737992 | 0.85 | NTSR1 (0.54) | PTGS2NTSR1CYP1A1CYP1B1SNCA | |
| SCHEMBL3742755 | 0.83 | NTSR1 (0.49) | PTGS2NTSR1CYP1A1CYP1B1SNCA | |
| SCHEMBL3733437 | 0.83 | ABCG2 (0.53) | CYP1A1CYP1B1CYP1A2MAPTTNFRSF1A | |
| SCHEMBL3732309 | 0.81 | CYP1A1 (0.68) | CYP1A1CYP1B1SNCAMAOBCYP1A2 | |
| SCHEMBL3734079 | 0.81 | CYP1A1 (0.47) | PTGS2CYP1A1CYP1B1TRPV1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | PTGS2 3118/4885NTSR1 33/4885CYP1A1 1184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.