SCHEMBL7079259

SCHEMBL7079259

Cc1ccc(-c2ccccc2)c(C(=O)Cl)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC7 Q8WUI4 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.48
CYP46A1 Q9Y6A2 3/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.46
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
HSD17B10 Q99714 1/20 0.45
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CSNK2A1 P68400 1/20 0.43
BCAT2 O15382 1/20 0.43
FABP3 P05413 1/20 0.43
FABP4 P15090 1/20 0.43
FOLH1 Q04609 1/20 0.42
CNR2 P34972 1/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
RAB9A P51151 1/20 0.42
ESR2 Q92731 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3733709 0.85 HDAC7 (0.60) HDAC7L3MBTL1CYP46A1PTGDR2KDM4E
SCHEMBL9271820 0.84 HDAC7 (0.58) HDAC7L3MBTL1CYP46A1PTGDR2KDM4E
SCHEMBL27438916 0.82 HDAC7 (0.57) HDAC7L3MBTL1CYP46A1PTGDR2KDM4E
SCHEMBL29135010 0.82 BCAT2 (0.61) HDAC7L3MBTL1CYP46A1PTGDR2KDM4E
SCHEMBL8585432 0.81 HDAC7 (0.60) HDAC7L3MBTL1CYP46A1PTGDR2KDM4E
SCHEMBL31290645 0.81 CYP46A1 (0.56) HDAC7L3MBTL1CYP46A1PTGDR2KDM4E
SCHEMBL10917657 0.81 BCAT2 (0.47) HDAC7ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL9490431 0.80 BCAT2 (0.44) ALDH1A1HSD17B10MEN1KMT2ASMN1; SMN2
SCHEMBL1775361 0.79 CYP46A1 (0.72) HDAC7L3MBTL1CYP46A1PTGDR2KDM4E
SCHEMBL9712480 0.79 HDAC7 (0.50) HDAC7L3MBTL1PTGDR2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-07-16 EP disclosed
WO-2002028835-A1 BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-04-11 WO disclosed