Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442956 | 0.90 | ALDH1A1 (0.43) | GPR84FFAR1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL9318505 | 0.90 | ALDH1A1 (0.43) | GPR84FFAR1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL9318736 | 0.90 | ALDH1A1 (0.43) | GPR84FFAR1CYP4F2CYP4A11ALDH1A1 | |
| Propylene Glycol SCHEMBL3739055 | 0.89 | TDP1 (0.40) | GPR84FFAR1TDP1CYP4F2CYP4A11 | |
| Ethylene Glycol SCHEMBL3728618 | 0.89 | TSHR (0.40) | GPR84CYP4F2CYP4A11ALDH1A1PPARG | |
| Hydrochloric Acid SCHEMBL9687274 | 0.88 | ALDH1A1 (0.41) | GPR84FFAR1CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL3733786 | 0.87 | TDP1 (0.44) | GPR84FFAR1TDP1CYP4F2CYP4A11 | |
| 1,4-Butanediol SCHEMBL3738766 | 0.87 | SMN1; SMN2 (0.41) | TDP1CYP4F2CYP4A11ALDH1A1PPARG | |
| SCHEMBL3733710 | 0.85 | TDP1 (0.45) | GPR84FFAR1TDP1CYP4F2CYP4A11 | |
| SCHEMBL8665961 | 0.84 | DNM1 (0.45) | GPR84FFAR1MAPTPLA2G4BPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101044221-B | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEM IND | 2012-06-20 | — | — | CN | disclosed |
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |
| CN-101044221-A | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEM IND (JP) | 2007-09-26 | — | — | CN | disclosed |