Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carglumic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.69 |
| ▸ | NAALAD2 | Q9Y3Q0 | 5/20 | 0.69 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.69 |
| ▸ | GNPAT | O15228 | 1/20 | 0.49 |
| ▸ | GGH | Q92820 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carglumic Acid SCHEMBL910483 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL910527 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27983953 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27983952 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27786751 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27772980 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL28084488 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27786752 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27873856 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27890153 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1552 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4649317-A2 | METHODS AND COMPOSITIONS FOR SCREENING AND TREATING ALZHEIMER'S DISEASE | Population Bio, Inc. (US) | 2025-11-19 | — | — | EP | claimed |
| EP-4637741-A1 | HOMOGENOUSLY SPLITTABLE TABLET COMPOSITIONS COMPRISING CARGLUMIC ACID | Santa Farma Ilac Sanayii A.S. (TR) | 2025-10-29 | — | — | EP | claimed |
| US-20250281517-A1 | SENOLYSIS BY AMMONIA-LOWERING COMPONENT | Taz Inc. (JP) | 2025-09-11 | — | — | US | claimed |
| EP-4110756-B1 | PROCESS FOR THE PURIFICATION OF CARGLUMIC ACID AND INTERMEDIATE OF THIS PROCESS | SCALE UP LABORATORY S R O (CZ) | 2025-08-13 | — | — | EP | claimed |
| CN-120188854-A | Nutritional feed based on urea and application of nutritional feed in ruminants | 云南牛牛牧业股份有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-119524462-B | Processing equipment and processing technology for N-carbamylglutamic acid | 锦州医科大学 | 2025-06-13 | — | — | CN | claimed |
| CN-119999817-A | Sheep feed based on silage tea leaves and preparation method and application thereof | 浙江工商大学 | 2025-05-16 | — | — | CN | claimed |
| CN-119404781-B | Bionic artificial propagation method for Dongxingqi | 海南晨海水产有限公司 | 2025-04-15 | — | — | CN | claimed |
| CN-119524462-A | Processing equipment and processing technology for NCG | 锦州医科大学 | 2025-02-28 | — | — | CN | claimed |
| CN-119523022-A | Nutritional additive for preventing and relieving livestock transportation stress and application thereof | 内蒙古自治区农牧业科学院 | 2025-02-28 | — | — | CN | claimed |
| CN-101565385-A | Pigling intestinal tract nutrition regulation and control substance N-carbamoylglutamine and preparation method | INST SUBTROPICAL AGRICULTUR (CN) | 2009-10-28 | — | — | CN | claimed |
| CN-101481336-A | Preparation of N-carbamoyl-aminoglutaric acid and sodium salt thereof | UNIV NANCHANG (CN) | 2009-07-15 | — | — | CN | claimed |
| WO-2008116165-A9 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY INC (US) | 2009-06-11 | — | — | WO | claimed |
| CN-101440042-A | Preparation of N-carbamylglutamic | BEIJING LONGKE FANGZHOU BIOLOG (CN) | 2009-05-27 | — | — | CN | claimed |
| WO-2008116165-A2 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| CN-101168518-A | Method for preparing N-carbamyl glutamic acid | YULONG YIN (CN) | 2008-04-30 | — | — | CN | claimed |
| US-20070036841-A1 | Method of enhancing an ornithine-urea cycle in ruminant gut tissues to detoxify ammonia and increase local urea recycling to the rumen for microbial protein synthesis | BEQUETTE BRIAN JAMES | 2007-02-15 | — | — | US | claimed |
| US-7157497-B2 | Method of enhancing an ornithine-urea cycle in ruminant gut tissues to detoxify ammonia and increase local urea recycling to the rumen for microbial protein synthesis | UNIVERSITY OF MARYLAND | 2007-01-02 | — | — | US | claimed |
| US-20040258736-A1 | Method of enhancing an ornithine-urea cycle in ruminant gut tissues to detoxify ammonia and increase local urea recycling to the rumen for microbial protein synthesis | UNIVERSITY OF MARYLAND | 2004-12-23 | — | — | US | claimed |
| EP-1209234-A1 | STEREOSTRUCTURE OF DECARBAMYLASE AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2002-05-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040258736-A1 | Method of enhancing an ornithine-urea cycle in ruminant gut tissues to detoxify ammonia and increase local urea recycling to the rumen for microbial protein synthesis | OAT, OTC, ODC1 | FOLH1 881/4885NAALAD2 481/4885RIMKLA 116/4885 |
| US-20070036841-A1 | Method of enhancing an ornithine-urea cycle in ruminant gut tissues to detoxify ammonia and increase local urea recycling to the rumen for microbial protein synthesis | OAT, OTC, ODC1 | FOLH1 881/4885NAALAD2 481/4885RIMKLA 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.