Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carglumic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.69 |
| ▸ | NAALAD2 | Q9Y3Q0 | 5/20 | 0.69 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.69 |
| ▸ | GNPAT | O15228 | 1/20 | 0.49 |
| ▸ | GGH | Q92820 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carglumic Acid SCHEMBL910483 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL373546 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27983953 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27983952 | 1.00 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27786751 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27772980 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL28084488 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27786752 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27873856 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH | |
| Carglumic Acid SCHEMBL27890153 | 0.98 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLAGNPATGGH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116390651-A | Methods of modulating gastrointestinal metabolites | 帝斯曼知识产权资产管理有限公司 | 2023-07-04 | — | — | CN | claimed |
| CN-1376202-A | Stereostructure of decarbamylase and use thereof | KANEGAFUCHI CHEMICAL IND (JP) | 2002-10-23 | — | — | CN | claimed |
| EP-1209234-A1 | STEREOSTRUCTURE OF DECARBAMYLASE AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2002-05-29 | — | — | EP | claimed |
| EP-4637741-A1 | HOMOGENOUSLY SPLITTABLE TABLET COMPOSITIONS COMPRISING CARGLUMIC ACID | Santa Farma Ilac Sanayii A.S. (TR) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024136769-A1 | HOMOGENOUSLY SPLITTABLE TABLET COMPOSITIONS COMPRISING CARGLUMIC ACID | SANTA FARMA ILAC SANAYII A.S. (TR) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024006841-A2 | COMPOSITIONS FOR WEIGHT LOSS AND CANCER TREATMENT | KNOWLEDGE PHARMACEUTICALS INC. (US) | 2024-01-04 | — | — | WO | disclosed |
| US-20230309502-A1 | ANIMAL LITTER COMPOSITIONS AND METHOD OF AMMONIA ABATEMENT | CONTROLLED RELEASE TECHNOLOGIES, INC. (US) | 2023-10-05 | — | — | US | disclosed |
| WO-2023158815-A1 | ANIMAL LITTER COMPOSITIONS AND METHOD OF AMMONIA ABATMENT | CONTROLLED RELEASE TECHNOLOGIES, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| CN-115315272-A | Targeting difunctional degradation agent | 耶鲁大学 | 2022-11-08 | — | — | CN | disclosed |
| US-20220296584-A1 | Membrane Active Molecules | KNOWLEDGE PHARMACEUTICALS INC. | 2022-09-22 | — | — | US | disclosed |
| US-20220128556-A1 | METHODS OF DIAGNOSING DISEASE | 4D Pharma Cork Limited (IE) | 2022-04-28 | — | — | US | disclosed |
| US-7118913-B2 | Expression vector containing urea cycle enzyme gene, transformant thereof, and use of transformant for protein over-expression | CHUNG-ANG UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR) | 2006-10-10 | — | — | US | disclosed |
| EP-1616945-A1 | Process for producing D-N-carbamoyl-alpha-amino acids | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2006-01-18 | — | — | EP | disclosed |
| EP-1616946-A1 | Process for producing D-N-carbamoyl-alpha-amino acids | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2006-01-18 | — | — | EP | disclosed |
| US-20050089849-A1 | Expression vector containing urea cycle enzyme gene, transformant thereof, and use of transformant for protein over-expression | CHUNG-ANG UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR) | 2005-04-28 | — | — | US | disclosed |
| CN-1376202-A | Stereostructure of decarbamylase and use thereof | KANEGAFUCHI CHEMICAL IND (JP) | 2002-10-23 | — | — | CN | disclosed |
| EP-1209234-A1 | STEREOSTRUCTURE OF DECARBAMYLASE AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2002-05-29 | — | — | EP | disclosed |
| WO-2002016626-A1 | EXPRESSION VECTOR CONTAINING UREA CYCLE ENZYME GENE, TRANSFORMANT THEREOF, AND USE OF TRANSFORMANT FOR PROTEIN OVER-EXPRESSION | INTERBIOGEN, INC. (KR) | 2002-02-28 | — | — | WO | disclosed |
| EP-0801131-A1 | PROCESS FOR PRODUCING D-N-CARBAMOYL-$g(a)-AMINO ACID | Kanegafuchi Chemical Industry Co., Ltd. (JP) | 1997-10-15 | — | — | EP | disclosed |
| US-4312948-A | AGROBACTERIUM CULTURE | SNAMPROGETTI S.P.A. (IT) | 1982-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220296584-A1 | Membrane Active Molecules | GABRP, GRIN3A, GRIN2A | FOLH1 2512/4885NAALAD2 1575/4885RIMKLA 420/4885 |
| US-20050089849-A1 | Expression vector containing urea cycle enzyme gene, transformant thereof, and use of transformant for protein over-expression | SLC14A1, OAT, ODC1 | FOLH1 709/4885NAALAD2 946/4885RIMKLA 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.