SCHEMBL373676

SCHEMBL373676

C=C(C)C(=O)Nc1cccc2c1C(=O)c1cccc(NC(=O)C(=C)C)c1C2=O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.64
TERT O14746 12/20 0.54
CASP3 P42574 1/20 0.51
MAPT P10636 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
EGFR P00533 1/20 0.49
PABPC1 P11940 1/20 0.49
MAPK1 P28482 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
ALDH1A1 P00352 2/20 0.46
GAA P10253 2/20 0.46
KDM4E B2RXH2 1/20 0.46
HPGD P15428 1/20 0.46
HSD17B10 Q99714 1/20 0.46
MEN1 O00255 1/20 0.46
POLB P06746 1/20 0.46
DNMT1 P26358 1/20 0.46
RAD52 P43351 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1993795 0.95 MAOA (0.72) MAOATERTCASP3MAPTTDP1
SCHEMBL648692 0.87 MAOA (0.55) MAOATERTMAPTTDP1RAB9A
SCHEMBL20334273 0.82 MAOA (0.90) MAOATERTCASP3MAPTTDP1
SCHEMBL10430973 0.79 MAOA (0.51) MAOATERTMAPTTDP1EGFR
SCHEMBL4296856 0.78 MAOA (0.57) MAOATERTCASP3MAPTTDP1
SCHEMBL6137259 0.78 CYP1A2 (0.52) MAOATERTMAPTTDP1PABPC1
SCHEMBL2601918 0.78 MAOA (1.00) MAOATERTCASP3MAPTTDP1
SCHEMBL6418936 0.78 NPC1 (0.59) MAPTTDP1MAPK1RAB9ASMN1; SMN2
SCHEMBL29986841 0.77 MAOA (0.87) MAOATERTCASP3MAPTTDP1
SCHEMBL11737076 0.77 TDP1 (0.51) MAPTTDP1RAB9AALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
EP-3992695-A1 OPHTHALMIC MEDICAL INSTRUMENT INCLUDING PHOTOCHROMIC POLYMER AND PRODUCTION METHOD FOR OPHTHALMIC MEDICAL INSTRUMENT Menicon Co., Ltd. (JP) 2022-05-04 EP disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
EP-3086163-B1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME MENICON CO LTD (JP) 2018-11-14 EP disclosed
EP-2857459-B1 STABLE POLYMERIZABLE UV-ABSORBING COLORANT FOR INTRAOCULAR LENS KOWA CO (JP) 2017-12-27 EP disclosed
US-9657131-B2 Ophthalmic lens MENICON CO., LTD. (JP) 2017-05-23 US disclosed
US-9650473-B2 Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same MENICON CO., LTD. (JP) 2017-05-16 US disclosed
US-5416180-A Fluorine containing (meth)acrylate polymers MENICON CO., LTD. (JP) 1995-05-16 US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed
EP-0381005-A2 Ocular lens material Menicon Co., Ltd. (JP) 1990-08-08 EP disclosed